Genes and Environment in Cancer

ISBN: 978-3-642-46872-8 (Print) 978-3-642-46870-4 (Online)

Table of contents (26 chapters)

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  1. Front Matter

    Pages I-XIV

  2. Key Notes

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-21

      Epidemiological Evidence of the Effects of Behaviour and the Environment on the Risk of Human Cancer

    3. No Access

      Book Chapter

      Pages 22-36

      Molecular Epidemiology of Human Cancer

  3. Risk Assessment and DNA Lesions

    1. Front Matter

      Pages 37-37

    2. No Access

      Book Chapter

      Pages 39-46

      Molecular Epidemiology of Environmental Carcinogenesis

    3. No Access

      Book Chapter

      Pages 47-85

      Polymorphisms of N-Acetyltransferases, Glutathione S-Transferases, Microsomal Epoxide Hydrolase and Sulfotransferases: Influence on Cancer Susceptibility

    4. No Access

      Book Chapter

      Pages 86-96

      Impact of Adduct Determination on the Assessment of Cancer Susceptibility

    5. No Access

      Book Chapter

      Pages 97-124

      Mutation Spectra Resulting from Carcinogenic Exposure: From Model Systems to Cancer-Related Genes

  4. DNA Repair and Genetic Susceptibility

    1. Front Matter

      Pages 125-125

    2. No Access

      Book Chapter

      Pages 127-146

      Relevance of DNA Repair to Carcinogenesis and Cancer Therapy

    3. No Access

      Book Chapter

      Pages 147-155

      Molecular Basis of DNA Repair Mechanisms and Syndromes

    4. No Access

      Book Chapter

      Pages 156-173

      The Ataxia Telangiectasia Gene in Familial and Sporadic Cancer

  5. Induced Chromosome Damage and Cancer

    1. Front Matter

      Pages 175-175

    2. No Access

      Book Chapter

      Pages 177-184

      Cancer Predictive Value of Cytogenetic Markers Used in Occupational Health Surveillance Programs

    3. No Access

      Book Chapter

      Pages 185-199

      Instability at Chromosomal Fragile Sites

    4. No Access

      Book Chapter

      Pages 200-215

      The Role of Deletions at the FRA3B/FHIT Locus in Carcinogenesis

    5. No Access

      Book Chapter

      Pages 216-226

      Gene Amplification Mechanisms: The Role of Fragile Sites

  6. Genetic Susceptibility and Environmental Exposure: “The RET Paradigm”

    1. Front Matter

      Pages 227-227

    2. No Access

      Book Chapter

      Pages 229-236

      Mechanisms of Development of Multiple Endocrine Neoplasia Type 2 and Hirschsprung’s Disease by ret Mutations

    3. No Access

      Book Chapter

      Pages 237-247

      Rearrangements of RET and NTRK1 Tyrosine Kinase Receptors in Papillary Thyroid Carcinomas

    4. No Access

      Book Chapter

      Pages 248-264

      Molecular Genetics of Childhood Papillary Thyroid Carcinomas After Irradiation: High Prevalence of RET Rearrangement

    5. No Access

      Book Chapter

      Pages 265-270

      Thyroid Carcinomas in RET/PTC Transgenic Mice

    6. No Access

      Book Chapter

      Pages 271-281

      Signal Transduction by the Receptor Tyrosine Kinase Ret

  7. Population Genetics of Cancer Susceptibility

    1. Front Matter

      Pages 283-283

    2. No Access

      Book Chapter

      Pages 285-291

      Complex Traits on the Map

    3. No Access

      Book Chapter

      Pages 292-297

      Genetic Mapping of Cancer Susceptibility/Resistance Loci in the Mouse

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