Book 2014


New and Old Molecules in the Fight Against Multi-resistant Bacteria


ISBN: 978-3-642-39967-1 (Print) 978-3-642-39968-8 (Online)

Table of contents (17 chapters)

  1. Front Matter

    Pages i-viii

  2. Current Trends in Antibiotics, Pathogens and Medical Needs

    1. Front Matter

      Pages 1-1

    2. Chapter

      Pages 3-10

      The Origin and Evolution of Antibiotics

    3. Chapter

      Pages 11-28

      Novel Infectious Diseases and Emerging Gram-Positive Multi-Resistant Pathogens in Hospital and Community Acquired Infections

    4. Chapter

      Pages 29-56

      Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugs

  3. Families of Novel Candidates and Conventional Antibiotics

    1. Front Matter

      Pages 57-57

    2. Chapter

      Pages 59-84

      The β-Lactam Antibiotics: Their Future in the Face of Resistance

    3. Chapter

      Pages 85-107

      Glycopeptides: An Old but Up-to-Date Successful Antibiotic Class

    4. Chapter

      Pages 109-139

      Daptomycin and Related Lipopeptides Produced by Fermentation, Chemical Modification, and Combinatorial Biosynthesis

    5. Chapter

      Pages 141-158

      Lantibiotics and Similar Peptides Produced by and Active on Gram-Positives: Discovery, Development and Perspectives

    6. Chapter

      Pages 159-175

      Old and Novel Polymyxins Against Serious Gram-Negative Infections

    7. Chapter

      Pages 177-191

      Uridyl Peptide Antibiotics: Developments in Biosynthesis and Medicinal Chemistry

    8. Chapter

      Pages 193-209

      Aminoglycoside Antibiotics

    9. Chapter

      Pages 211-230

      Macrolide Antibiotics

    10. Chapter

      Pages 231-245

      Tetracycline Antibiotics and Novel Analogs

    11. Chapter

      Pages 247-266

      Oxazolidin-2-Ones: Antibacterial Activity and Chemistry

    12. Chapter

      Pages 267-286

      Protein Synthesis Inhibitors from Smaller Antibiotic Classes

    13. Chapter

      Pages 287-305

      Actinonin and Analogs: Inhibitors of Bacterial Peptide Deformylase

    14. Chapter

      Pages 307-326

      Bacterial Topoisomerase Inhibitors: Quinolones and Beyond

    15. Chapter

      Pages 327-360

      Strategies to Discover Novel Antimicrobials to Cope with Emerging Medical Needs

  4. Back Matter

    Pages 361-364