Pharmacotherapy of Pulmonary Hypertension

Editors:

ISBN: 978-3-642-38663-3 (Print) 978-3-642-38664-0 (Online)

Table of contents (22 chapters)

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  1. Front Matter

    Pages i-ix

  2. Pulmonary Hypertension: Conceptual Bases of the Disease

    1. Front Matter

      Pages 1-1

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      Chapter

      Pages 3-29

      Definition and Classification of Pulmonary Hypertension

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      Chapter

      Pages 31-58

      Pulmonary Hypertension: Pathophysiology and Signaling Pathways

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      Chapter

      Pages 59-75

      Pulmonary Hypertension: Pathology

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      Chapter

      Pages 77-103

      Pulmonary Hypertension: Biomarkers

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      Chapter

      Pages 105-149

      Rodent Models of Group 1 Pulmonary Hypertension

  3. Pulmonary Hypertension: Established Therapies

    1. Front Matter

      Pages 151-151

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      Chapter

      Pages 153-160

      General Supportive Care

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      Chapter

      Pages 161-175

      Calcium-Channel Blockers in Pulmonary Arterial Hypertension

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      Chapter

      Pages 177-198

      Prostacyclins

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      Chapter

      Pages 199-227

      Endothelin Receptor Antagonists

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      Chapter

      Pages 229-255

      Phosphodiesterase-5 Inhibitors

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      Chapter

      Pages 257-276

      Inhaled Nitric Oxide for the Treatment of Pulmonary Arterial Hypertension

  4. Pulmonary Hypertension: Novel Pathways and Emerging Therapies

    1. Front Matter

      Pages 277-277

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      Chapter

      Pages 279-313

      Soluble Guanylate Cyclase Stimulators in Pulmonary Hypertension

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      Chapter

      Pages 315-349

      Therapeutics Targeting of Dysregulated Redox Equilibrium and Endothelial Dysfunction

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      Chapter

      Pages 351-363

      Rho-Kinase Inhibitors

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      Chapter

      Pages 365-380

      Serotonin Transporter and Serotonin Receptors

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      Chapter

      Pages 381-408

      Targeting of Platelet-Derived Growth Factor Signaling in Pulmonary Arterial Hypertension

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      Chapter

      Pages 409-436

      Emerging Molecular Targets for Anti-proliferative Strategies in Pulmonary Arterial Hypertension

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      Chapter

      Pages 437-476

      Anti-inflammatory and Immunosuppressive Agents in PAH

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      Chapter

      Pages 477-511

      Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application

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      Chapter

      Pages 513-529

      Pulmonary Hypertension: Novel Pathways and Emerging Therapies Inhibitors of cGMP and cAMP Metabolism

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