2012

Drug Discovery in Africa

Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs

Editors:

ISBN: 978-3-642-28174-7 (Print) 978-3-642-28175-4 (Online)

Table of contents (17 chapters)

  1. Front Matter

    Pages i-xx

  2. No Access

    Book Chapter

    Pages 1-28

    Overview of Current Drug Discovery Activities in Africa and Their Links to International Efforts to Combat Tropical Infectious Diseases

  3. No Access

    Book Chapter

    Pages 29-52

    The National Cancer Institute and Natural Product-Based Drug Discovery in Africa

  4. No Access

    Book Chapter

    Pages 53-84

    Tuberculosis Drug Discovery: Target Identification and Validation

  5. No Access

    Book Chapter

    Pages 85-99

    Targeting Conserved Pathways as a Strategy for Novel Drug Development: Disabling the Cellular Stress Response

  6. No Access

    Book Chapter

    Pages 101-126

    Natural Product-Based Drug Discovery in Africa: The Need for Integration into Modern Drug Discovery Paradigms

  7. No Access

    Book Chapter

    Pages 127-150

    Searching for Drugs That Target Multiple Receptors for Anthelmintics from African Natural Products

  8. No Access

    Book Chapter

    Pages 151-191

    Application of In Silico, In Vitro and In Vivo ADMET/PK Platforms in Drug Discovery

  9. No Access

    Book Chapter

    Pages 193-209

    Marine Bioprospecting in Southern Africa

  10. No Access

    Book Chapter

    Pages 211-237

    Natural Product-Based Drug Discovery Against Neglected Diseases with Special Reference to African Natural Resources

  11. No Access

    Book Chapter

    Pages 239-264

    “Now I Heal with Pride”—The Application of Screens-to-Nature Technology to Indigenous Knowledge Systems Research in Botswana: Implications for Drug Discovery

  12. No Access

    Book Chapter

    Pages 265-292

    Innovative Approaches to Exploiting Traditional Medicines in Malaria

  13. No Access

    Book Chapter

    Pages 293-300

    Anticancer Drug Repositioning Against Tropical Diseases: The Example of Methotrexate in the Treatment of Malaria

  14. No Access

    Book Chapter

    Pages 301-324

    Tackling the Problem of Antimalarial Resistance

  15. No Access

    Book Chapter

    Pages 325-354

    Random and Rational Approaches to HIV Drug Discovery in Africa

  16. No Access

    Book Chapter

    Pages 355-377

    Structure-Based Design of Domain-Selective Angiotensin-Converting Enzyme Inhibitors

  17. No Access

    Book Chapter

    Pages 379-406

    Natural Products and Antimalarial Drugs: Will Africa Provide the Next Major Breakthrough?

  18. No Access

    Book Chapter

    Pages 407-429

    Nanomedicine in the Development of Drugs for Poverty-Related Diseases

  19. Back Matter

    Pages 431-438