Theranostics, Gallium-68, and Other Radionuclides

A Pathway to Personalized Diagnosis and Treatment

Editors:

ISBN: 978-3-642-27993-5 (Print) 978-3-642-27994-2 (Online)

Table of contents (34 chapters)

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  1. Front Matter

    Pages i-xviii

  2. Generators

    1. Front Matter

      Pages 1-1

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      Pages 3-16

      68 Ge/ 68 Ga Generators: Past, Present, and Future

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      Pages 17-31

      Overview and Perspectives on Automation Strategies in 68 Ga Radiopharmaceutical Preparations

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      Pages 33-42

      Post-Processing via Cation Exchange Cartridges: Versatile Options

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      Pages 43-75

      68 Ga Generator Integrated System: Elution–Purification–Concentration Integration

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      Pages 77-87

      Purification and Labeling Strategies for 68 Ga from 68 Ge/ 68 Ga Generator Eluate

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      Pages 89-97

      67 Ga and 68 Ga Purification Studies: Preliminary Results

  3. Radiochemistry and Radiopharmacy

    1. Front Matter

      Pages 99-99

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      Pages 101-131

      The Diversity of 68 Ga-Based Imaging Agents

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      Pages 133-147

      Nanoparticles and Phage Display Selected Peptides for Imaging and Therapy of Cancer

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      Pages 149-175

      “Click”-Cyclized 68 Ga-Labeled Peptides for Molecular Imaging and Therapy: Synthesis and Preliminary In Vitro and In Vivo Evaluation in a Melanoma Model System

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      Pages 177-188

      Early Experience with 68 Ga-DOTATATE Preparation

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      Pages 189-219

      68 Ga-Radiopharmaceuticals for PET Imaging of Infection and Inflammation

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      Pages 221-256

      68 Ga-Labeled Bombesin Analogs for Receptor-Mediated Imaging

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      Pages 257-267

      A Novel 68 Ga-Labeled Pteroic Acid-Based PET Tracer for Tumor Imaging via the Folate Receptor

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      Pages 269-283

      Measurement of Protein Synthesis: In Vitro Comparison of 68 Ga-DOTA-Puromycin, [ 3 H]Tyrosine, and 2-Fluoro-[ 3 H]tyrosine

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      Pages 285-299

      Hypoxia Imaging Agents Labeled with Positron Emitters

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      Pages 301-317

      177 Lu/ 90 Y Intermediate-Affinity Monoclonal Antibodies Targeting EGFR and HER2/c-neu: Preparation and Preclinical Evaluation

  4. Molecular Imaging Using Ga-68 labeled Tracers

    1. Front Matter

      Pages 319-319

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      Pages 321-351

      Divergent Role of 68 Ga-Labeled Somatostatin Analogs in the Workup of Patients with NETs: AIIMS Experience

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      Pages 353-371

      Differential Uptake of 68 Ga-DOTATOC and 68 Ga-DOTATATE in PET/CT of Gastroenteropancreatic Neuroendocrine Tumors

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      Pages 373-378

      High Uptake of 68 Ga-DOTATOC in Spleen as Compared to Splenosis: Measurement by PET/CT

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      Pages 379-384

      Rare Metastases Detected by 68 Ga-Somatostatin Receptor PET/CT in Patients with Neuroendocrine Tumors

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