From Nucleic Acids Sequences to Molecular Medicine

Editors:

ISBN: 978-3-642-27425-1 (Print) 978-3-642-27426-8 (Online)

Table of contents (26 chapters)

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  1. Front Matter

    Pages i-ix

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    Book Chapter

    Pages 1-18

    RNAissance

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    Book Chapter

    Pages 19-45

    Nucleic Acids as Therapeutics

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    Book Chapter

    Pages 47-65

    Thio Effects as a Tool for Mechanistic Studies of the Cleavage of RNA Phosphodiester Bonds: The Chemical Basis

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    Book Chapter

    Pages 67-83

    Off-Target Effects and Safety Aspects of Phosphorothioate Oligonucleotides

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    Book Chapter

    Pages 85-120

    Oligonucleotide Conjugates: Rationale, Synthesis, and Applications

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    Book Chapter

    Pages 121-143

    CRISPR: A Bacterial Immunity System Based on Small RNAs

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    Book Chapter

    Pages 145-189

    Antisense Technology: From Unique Laboratory Tool to Novel Anticancer Treatments

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    Book Chapter

    Pages 191-214

    Antisense-Mediated Reduction of Eukaryotic Noncoding RNAs

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    Book Chapter

    Pages 215-246

    Antisense Oligonucleotides in the Treatment of Malignant Gliomas

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    Book Chapter

    Pages 247-274

    Natural Antisense Transcripts Mediate Regulation of Gene Expression

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    Book Chapter

    Pages 275-291

    Activation and Deactivation of Antisense and RNA Interference Function with Light

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    Book Chapter

    Pages 293-312

    Ribozymes as Molecular Biology Reagents

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    Book Chapter

    Pages 313-356

    RNA Technologies for Mitochondrial Genetics

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    Book Chapter

    Pages 357-370

    RNA-Based Therapies for Inherited Metabolic Diseases

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    Book Chapter

    Pages 371-410

    RNA-Cleaving DNA Enzymes and Their Potential Therapeutic Applications as Antibacterial and Antiviral Agents

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    Book Chapter

    Pages 411-427

    Hammerhead Ribozymes Against Virus and Viroid RNAs

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    Book Chapter

    Pages 429-452

    Suppression of Hepatitis C Viral Genome Replication with RNA-Cleaving Deoxyribozyme

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    Book Chapter

    Pages 453-473

    Design of Synthetic shRNAs for Targeting Hepatitis C: A New Approach to Antiviral Therapeutics

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    Book Chapter

    Pages 475-501

    The Diverse Active Sites in Splicing, Debranching, and MicroRNA Processing Around RNA Phosphodiester Bonds

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    Book Chapter

    Pages 503-523

    MicroRNAs and Their Antagonists as Novel Therapeutics

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