2012

Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Order-Restricted Analysis of Microarray Data

ISBN: 978-3-642-24006-5 (Print) 978-3-642-24007-2 (Online)

Table of contents (18 chapters)

  1. Front Matter

    Pages i-xv

  2. Dose-response Modeling: An Introduction

    1. Front Matter

      Pages 9-9

    2. No Access

      Book Chapter

      Pages 1-7

      Introduction

    3. No Access

      Book Chapter

      Pages 11-27

      Estimation Under Order Restrictions

    4. No Access

      Book Chapter

      Pages 29-42

      Testing of Equality of Means Against Ordered Alternatives

    5. No Access

      Book Chapter

      Pages 43-66

      Nonlinear Modeling of Dose-Response Data

  3. Dose-response Microarray Experiments

    1. Front Matter

      Pages 67-67

    2. No Access

      Book Chapter

      Pages 69-80

      Functional Genomic Dose-Response Experiments

    3. No Access

      Book Chapter

      Pages 81-101

      Adjustment for Multiplicity

    4. No Access

      Book Chapter

      Pages 103-121

      Single Contrast Tests

    5. No Access

      Book Chapter

      Pages 123-133

      Significance Analysis of Dose-Response Microarray Data

    6. No Access

      Book Chapter

      Pages 135-149

      δ-Clustering of Monotone Profiles

    7. No Access

      Book Chapter

      Pages 151-163

      Classification of Monotone Gene Profiles Using Information Theory Selection Methods

    8. No Access

      Book Chapter

      Pages 165-180

      Beyond the Simple Order Alternatives

    9. No Access

      Book Chapter

      Pages 181-191

      Gene Set Analysis as a Means of Facilitating the Interpretation of Microarray Results

    10. No Access

      Book Chapter

      Pages 193-214

      Estimation and Inference Under Simple Order Restrictions: Hierarchical Bayesian Approach

    11. No Access

      Book Chapter

      Pages 215-232

      Model-Based Approaches

    12. No Access

      Book Chapter

      Pages 233-247

      Multiple Contrast Tests for Testing Dose–Response Relationships Under Order-Restricted Alternatives

    13. No Access

      Book Chapter

      Pages 249-258

      Simultaneous Inferences for Ratio Parameters Using Multiple Contrasts Test

    14. No Access

      Book Chapter

      Pages 259-267

      Multiple Confidence Intervals for Selected Ratio Parameters Adjusted for the False Coverage-Statement Rate

    15. No Access

      Book Chapter

      Pages 269-279

      Interfaces for Analyzing Dose–Response Studies in Microarray Experiments: IsoGeneGUI and ORIOGEN

  4. Back Matter

    Pages 281-282