Book 2012

Dupuytren’s Disease and Related Hyperproliferative Disorders

Principles, Research, and Clinical Perspectives

ISBN: 978-3-642-22696-0 (Print) 978-3-642-22697-7 (Online)

Table of contents (54 chapters)

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  1. Front Matter

    Pages i-xxiii

  2. Anatomy, Pathology, and Pathophysiology

    1. Front Matter

      Pages 1-1

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      Chapter

      Pages 3-10

      Dupuytren’s Disease: Anatomy, Pathology, and Presentation

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      Chapter

      Pages 11-20

      Palmar Fibromatosis or the Loss of Flexibility of the Palmar Finger Tissue: A New Insight into the Disease Process of Dupuytren Contracture

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      Chapter

      Pages 21-26

      Basic Thoughts on Dupuytren’s Contracture

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      Chapter

      Pages 27-34

      High Prevalence of Dupuytren’s Disease and Its Treatment in the British National Health Service: An Ongoing Demand

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      Chapter

      Pages 35-43

      Treatment for Dupuytren’s Disease: An Overview of Options

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      Chapter

      Pages 45-49

      Dupuytren’s Disease and Occupation

  3. The Myofibroblast

    1. Front Matter

      Pages 51-51

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      Chapter

      Pages 53-60

      The Role of the Myofibroblast in Dupuytren’s Disease: Fundamental Aspects of Contraction and Therapeutic Perspectives

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      Chapter

      Pages 61-67

      Mechanisms of Myofibroblast Differentiation

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      Chapter

      Pages 69-75

      Myofibroblasts and Interactions with Other Cells: Contribution of the Tissue Engineering

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      Chapter

      Pages 77-83

      Dupuytren’s Contracture Versus Burn Scar Contracture

  4. Genetics and Demographics

    1. Front Matter

      Pages 85-85

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      Chapter

      Pages 87-91

      The Genetic Basis of Dupuytren’s Disease: An Introduction

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      Chapter

      Pages 93-100

      Use of Genetic and Genomic Analyses Tools to Study Dupuytren’s Disease

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      Chapter

      Pages 101-108

      Establishing an Animal Model of Dupuytren’s Contracture by Profiling Genes Associated with Fibrosis

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      Chapter

      Pages 109-113

      Microarray Expression Analysis of Primary Dupuytren’s Contracture Cells

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      Chapter

      Pages 115-122

      A Clinical Genetic Study of Familial Dupuytren’s Disease in the Netherlands

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      Chapter

      Pages 123-127

      The Epidemiology of Dupuytren’s Disease in Bosnia

  5. Collagen and Cell Biology

    1. Front Matter

      Pages 129-129

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      Chapter

      Pages 131-142

      A Primer of Collagen Biology: Synthesis, Degradation, Subtypes, and Role in Dupuytren’s Disease

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      Chapter

      Pages 143-149

      The Expression of Collagen-Degrading Proteases Involved in Dupuytren’s Disease Fibroblast-Mediated Contraction

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      Chapter

      Pages 151-159

      Primary Dupuytren’s Disease Cell Interactions with the Extra-cellular Environment: A Link to Disease Progression?

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      Chapter

      Pages 161-165

      Insulin-Like Growth Factor Binding Protein-6: A Potential Mediator of Myofibroblast Differentiation in Dupuytren’s Disease?

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