Histone Deacetylases: the Biology and Clinical Implication


ISBN: 978-3-642-21630-5 (Print) 978-3-642-21631-2 (Online)

Table of contents (11 chapters)

  1. Front Matter

    Pages i-xi

  2. Chapter

    Pages 1-12

    K-Acetylation and Its Enzymes: Overview and New Developments

  3. Chapter

    Pages 13-37

    The Biology of HDAC in Cancer: The Nuclear and Epigenetic Components

  4. Chapter

    Pages 39-56

    Deacetylation of Nonhistone Proteins by HDACs and the Implications in Cancer

  5. Chapter

    Pages 57-78

    The Biology and Therapeutic Implications of HDACs in the Heart

  6. Chapter

    Pages 79-101

    HDACs in Skeletal Muscle Remodeling and Neuromuscular Disease

  7. Chapter

    Pages 103-123

    Rationale for HDAC Inhibitor Therapy in Autoimmunity and Transplantation

  8. Chapter

    Pages 125-162

    The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity

  9. Chapter

    Pages 163-188

    Mitochondrial Sirtuins in the Regulation of Mitochondrial Activity and Metabolic Adaptation

  10. Chapter

    Pages 189-224

    Characterization of Nuclear Sirtuins: Molecular Mechanisms and Physiological Relevance

  11. Chapter

    Pages 225-240

    Structural Biology of Human Metal-Dependent Histone Deacetylases

  12. Chapter

    Pages 241-255

    Sirtuin Modulators

  13. Back Matter

    Pages 257-260