Book 2011

Bispecific Antibodies


ISBN: 978-3-642-20909-3 (Print) 978-3-642-20910-9 (Online)

Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvii

  2. Chapter

    Pages 1-28

    Bispecific Antibodies: Developments and Current Perspectives

  3. Chapter

    Pages 29-46

    Bispecific Antibodies from Hybrid Hybridoma

  4. Chapter

    Pages 47-63

    Generation of Bispecific Antibodies by Chemical Conjugation

  5. Chapter

    Pages 65-82

    Trivalent and Trispecific Antibody Derivatives for Cancer Therapy

  6. Chapter

    Pages 83-100

    Diabodies, Single-Chain Diabodies, and Their Derivatives

  7. Chapter

    Pages 101-114

    Bispecific Single Domain Antibodies

  8. Chapter

    Pages 115-133

    Alternative Scaffolds as Bispecific Antibody Mimetics

  9. Chapter

    Pages 135-149

    Tribodies: Fab–scFv Fusion Proteins as a Platform to Create Multifunctional Pharmaceuticals

  10. Chapter

    Pages 151-169

    The Design and Engineering of IgG-Like Bispecific Antibodies

  11. Chapter

    Pages 171-185

    Dual-Variable Domain Immunoglobulin (DVD-Ig™) Technology: A Versatile, Novel Format for the Next Generation of Dual-Targeting Biologics

  12. Chapter

    Pages 187-198

    Two-in-One Antibodies

  13. Chapter

    Pages 199-216

    The Dock-and-Lock (DNL) Approach to Novel Bispecific Antibodies

  14. Chapter

    Pages 217-241

    Effector Cell Recruitment by Bispecific Antibodies

  15. Chapter

    Pages 243-271

    Bispecific Antibodies for Arming Activated T Cells and Other Effector Cells for Tumor Therapy

  16. Chapter

    Pages 273-287

    Bispecific T Cell Engager for Cancer Therapy

  17. Chapter

    Pages 289-312

    Trifunctional Triomab® Antibodies for Cancer Therapy

  18. Chapter

    Pages 313-326

    Bispecific Antibodies for the Retargeting of Cytokines

  19. Chapter

    Pages 327-347

    Bispecific Antibodies and Gene Therapy

  20. Chapter

    Pages 349-367

    Bispecific Antibodies for Diagnostic Applications

  21. Back Matter

    Pages 369-373