Phosphodiesterases as Drug Targets


ISBN: 978-3-642-17968-6 (Print) 978-3-642-17969-3 (Online)

Table of contents (20 chapters)

  1. Front Matter

    Pages i-xvii

  2. Chapter

    Pages 1-46

    Phosphodiesterase Inhibitors: History of Pharmacology

  3. Chapter

    Pages 47-84

    Phosphodiesterase Inhibitors: Factors That Influence Potency, Selectivity, and Action

  4. Chapter

    Pages 85-119

    Pharmacology, Clinical Efficacy, and Tolerability of Phosphodiesterase-4 Inhibitors: Impact of Human Pharmacokinetics

  5. Chapter

    Pages 121-134

    Structural Insight into the Substrate Specificity of Phosphodiesterases

  6. Chapter

    Pages 135-149

    A Fission Yeast-Based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity

  7. Chapter

    Pages 151-166

    The GAF-Tandem Domain of Phosphodiesterase 5 as a Potential Drug Target

  8. Chapter

    Pages 167-192

    Small Molecule Allosteric Modulators of Phosphodiesterase 4

  9. Chapter

    Pages 193-210

    Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases

  10. Chapter

    Pages 211-236

    Phosphodiesterases as Targets for Intermittent Claudication

  11. Chapter

    Pages 237-249

    Phosphodiesterase Inhibition in Heart Failure

  12. Chapter

    Pages 251-277

    Phosphodiesterases: Emerging Therapeutic Targets for Neonatal Pulmonary Hypertension

  13. Chapter

    Pages 279-305

    Role of Phosphodiesterases in Adult-Onset Pulmonary Arterial Hypertension

  14. Chapter

    Pages 307-322

    Treatment of Erectile Dysfunction and Lower Urinary Tract Symptoms by Phosphodiesterase Inhibitors

  15. Chapter

    Pages 323-344

    Evaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx Mouse Model of Duchenne Muscular Dystrophy

  16. Chapter

    Pages 345-363

    Phosphodiesterases as Targets for Modulating T-Cell Responses

  17. Chapter

    Pages 365-390

    Cyclic Nucleotides and Phosphodiesterases in Monocytic Differentiation

  18. Chapter

    Pages 391-414

    Phosphodiesterase Inhibitors in the Treatment of Inflammatory Diseases

  19. Chapter

    Pages 415-446

    Harnessing the Clinical Efficacy of Phosphodiesterase 4 Inhibitors in Inflammatory Lung Diseases: Dual-Selective Phosphodiesterase Inhibitors and Novel Combination Therapies

  20. Chapter

    Pages 447-485

    Phosphodiesterases in the Central Nervous System: Implications in Mood and Cognitive Disorders

  21. Chapter

    Pages 487-510

    Therapeutic Potential of Phosphodiesterase Inhibitors in Parasitic Diseases

  22. Back Matter

    Pages 511-519