2011

Heart Rate and Rhythm

Molecular Basis, Pharmacological Modulation and Clinical Implications

Editors:

ISBN: 978-3-642-17574-9 (Print) 978-3-642-17575-6 (Online)

Table of contents (37 chapters)

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  1. Front Matter

    Pages i-xxii

  2. Normal Cardiac Rhythm and Pacemaker Activity

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-31

      Cardiac Ion Channels and Heart Rate and Rhythm

    3. No Access

      Book Chapter

      Pages 33-58

      Ionic Basis of the Pacemaker Activity of SA Node Revealed by the Lead Potential Analysis

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      Book Chapter

      Pages 59-81

      The “Funny” Pacemaker Current

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      Book Chapter

      Pages 83-99

      Novel Perspectives on Cardiac Pacemaker Regulation: Role of the Coupled Function of Sarcolemmal and Intracellular Proteins

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      Book Chapter

      Pages 101-117

      Pacemaker Activity of the SA Node: Insights from Dynamic-Clamp Experiments

    7. No Access

      Book Chapter

      Pages 119-132

      Heart Rate Variability: Molecular Mechanisms and Clinical Implications

    8. No Access

      Book Chapter

      Pages 133-151

      Mechano-Electric Feedback in the Heart: Effects on Heart Rate and Rhythm

  3. Modeling

    1. Front Matter

      Pages 153-153

    2. No Access

      Book Chapter

      Pages 155-173

      A Historical Perspective on the Development of Models of Rhythm in the Heart

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      Book Chapter

      Pages 175-194

      Simulation of Cardiac Action Potentials

  4. Cardiac Development and Anatomy

    1. Front Matter

      Pages 195-195

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      Book Chapter

      Pages 197-209

      Development of Pacemaker Activity in Embryonic and Embryonic Stem Cell-Derived Cardiomyocytes

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      Book Chapter

      Pages 211-230

      Molecular Basis of the Electrical Activity of the Atrioventricular Junction and Purkinje Fibres

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      Book Chapter

      Pages 231-253

      Molecular Basis and Genetic Aspects of the Development of the Cardiac Chambers and Conduction System: Relevance to Heart Rhythm

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      Book Chapter

      Pages 255-266

      Role of the T-Tubules in the Response of Cardiac Ventricular Myocytes to Inotropic Interventions

  5. Mechanisms of Acquired Arrhythmia

    1. Front Matter

      Pages 267-267

    2. No Access

      Book Chapter

      Pages 269-282

      An Overview of Spiral- and Scroll-Wave Dynamics in Mathematical Models for Cardiac Tissue

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      Book Chapter

      Pages 283-304

      Post-infarction Remodeling and Arrhythmogenesis: Molecular, Ionic, and Electrophysiological Substrates

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      Book Chapter

      Pages 305-322

      The Role of Intracellular Ca2+ in Arrhythmias in the Postmyocardial Infarction Heart

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      Book Chapter

      Pages 323-335

      Molecular and Biochemical Characteristics of the Intracellular Ca2+ Handling Proteins in the Heart

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      Book Chapter

      Pages 337-349

      Pharmacological Modulation and Clinical Implications of Sarcolemmal Ca2+-Handling Proteins in Heart Function

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      Book Chapter

      Pages 351-364

      Calmodulin Kinase II Regulation of Heart Rhythm and Disease

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      Book Chapter

      Pages 365-383

      MicroRNA and Pluripotent Stem Cell-Based Heart Therapies: The Electrophysiological Perspective

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