Phosphoinositide 3-kinase in Health and Disease

Volume 2


ISBN: 978-3-642-14815-6 (Print) 978-3-642-14816-3 (Online)

Table of contents (13 chapters)

  1. Front Matter

    Pages i-x

  2. Chapter

    Pages 1-19

    PI3K: From the Bench to the Clinic and Back

  3. Chapter

    Pages 21-41

    Oncogenic Mutations of PIK3CA in Human Cancers

  4. Chapter

    Pages 43-53

    Structural Effects of Oncogenic PI3Kα Mutations

  5. Chapter

    Pages 55-77

    Comparing the Roles of the p110α and p110β Isoforms of PI3K in Signaling and Cancer

  6. Chapter

    Pages 79-104

    Phosphatidylinositol 3-Kinase: The Oncoprotein

  7. Chapter

    Pages 105-133

    AKT Signaling in Physiology and Disease

  8. Chapter

    Pages 135-168

    Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse

  9. Chapter

    Pages 169-188

    PI3K as a Target for Therapy in Haematological Malignancies

  10. Chapter

    Pages 189-208

    Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors

  11. Chapter

    Pages 209-239

    From the Bench to the Bed Side: PI3K Pathway Inhibitors in Clinical Development

  12. Chapter

    Pages 241-262

    New Inhibitors of the PI3K-Akt-mTOR Pathway: Insights into mTOR Signaling from a New Generation of Tor Kinase Domain Inhibitors (TORKinibs)

  13. Chapter

    Pages 263-278

    Small Molecule Inhibitors of the PI3-Kinase Family

  14. Chapter

    Pages 279-296

    Targeting the RTK-PI3K-mTOR Axis in Malignant Glioma: Overcoming Resistance

  15. Back Matter

    Pages 297-304