Adverse Drug Reactions

Editors:

ISBN: 978-3-642-00662-3 (Print) 978-3-642-00663-0 (Online)

Table of contents (19 chapters)

  1. Front Matter

    Pages 1-9

  2. Target Organ Toxicity

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-27

      Drug-Induced Liver Injury

    3. No Access

      Book Chapter

      Pages 29-55

      Drug Hypersensitivity Reactions Involving Skin

    4. No Access

      Book Chapter

      Pages 57-76

      Adverse Drug Reactions Affecting Blood Cells

    5. No Access

      Book Chapter

      Pages 77-109

      Molecular Mechanisms of Adverse Drug Reactions in Cardiac Tissue

    6. No Access

      Book Chapter

      Pages 111-130

      Mechanisms of Drug-Induced Nephrotoxicity

    7. No Access

      Book Chapter

      Pages 131-162

      Receptor- and Reactive Intermediate-Mediated Mechanisms of Teratogenesis

  3. Mediators/Biochemical Pathways

    1. Front Matter

      Pages 164-164

    2. No Access

      Book Chapter

      Pages 165-194

      Role of Reactive Metabolites in Drug-Induced Hepatotoxicity

    3. No Access

      Book Chapter

      Pages 195-231

      The Role of Cytokines in the Mechanism of Adverse Drug Reactions

    4. No Access

      Book Chapter

      Pages 233-266

      The Keap1-Nrf2 Cellular Defense Pathway: Mechanisms of Regulation and Role in Protection Against Drug-Induced Toxicity

    5. No Access

      Book Chapter

      Pages 267-310

      Signal Transduction Pathways Involved in Drug-Induced Liver Injury

    6. No Access

      Book Chapter

      Pages 311-365

      Mitochondrial Involvement in Drug-Induced Liver Injury

  4. Examples/Models

    1. Front Matter

      Pages 368-368

    2. No Access

      Book Chapter

      Pages 369-405

      Mechanisms of Acetaminophen-Induced Liver Necrosis

    3. No Access

      Book Chapter

      Pages 407-418

      Drug-Induced Liver Injury in Humans: The Case of Ximelagatran

    4. No Access

      Book Chapter

      Pages 419-435

      Troglitazone

    5. No Access

      Book Chapter

      Pages 437-451

      Nevirapine Hypersensitivity

    6. No Access

      Book Chapter

      Pages 453-474

      Mechanisms of Adverse Drug Reactions to Biologics

  5. Risk Factors/Screening Drug Candidates

    1. Front Matter

      Pages 476-476

    2. No Access

      Book Chapter

      Pages 477-491

      Pharmacogenetics of Idiosyncratic Adverse Drug Reactions

    3. No Access

      Book Chapter

      Pages 493-509

      The Danger Hypothesis Applied to Idiosyncratic Drug Reactions

    4. No Access

      Book Chapter

      Pages 511-544

      Approaches for Minimizing Metabolic Activation of New Drug Candidates in Drug Discovery

  6. Back Matter

    Pages 1-12