Sparking Signals

Kinases as Molecular Signaltransducers and Pharmacological Drug Targets in Inflammation

  • Editors
  • G. Baier
  • B. Schraven
  • U. Zügel
  • A. von Bonin
Conference proceedings

DOI: 10.1007/978-3-540-73501-4

Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2007/3)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. M. Bantscheff, C. Hopf, U. Kruse, G. Drewes
    Pages 1-28
  3. J. A. Lindquist, B. Schraven
    Pages 186-206
  4. M. Koziczak-Holbro, C. Joyce, A. Glück, B. Kinzel, M. Müller, H. Gram
    Pages 263-282
  5. J. L. de Diego, G. Gerold, A. Zychlinsky
    Pages 293-395
  6. X. P. Zhong, B. A. Olenchock, G. A. Koretzky
    Pages 396-449

About these proceedings

Introduction

Protein phosphorylation is an essential post-translational modification that modulates cell–cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.

Keywords

Cellular Signalling Drug Finding Immune-modulation Kinase Inhibitors Proteomics Translation metabolism

Bibliographic information

  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-73500-7
  • Online ISBN 978-3-540-73501-4
  • Series Print ISSN 0947-6075