Progestins and the Mammary Gland

From Basic Science to Clinical Applications

  • Editors
  • O. Conneely
  • C. Otto
Conference proceedings

DOI: 10.1007/978-3-540-73493-2

Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2007/1)

Table of contents (9 papers)

  1. Front Matter
    Pages i-xvii
  2. Steroid Receptor Coactivator 2: An Essential Coregulator of Progestin-Induced Uterine and Mammary Morphogenesis
    A. Mukherjee, P. Amato, D. Craig-Allred, F. J. DeMayo, B. W. O'Malley, J. P. Lydon
    Pages 55-76
  3. Inhibition of Mammary Tumorigenesis by Estrogen and Progesterone in Genetically Engineered Mice
    D. Medina, F. S. Kittrell, A. Tsimelzon, S. A. W. Fuqua
    Pages 109-126
  4. Estrogens, Progestins, and Risk of Breast Cancer
    M. C. Pike, A. H. Wu, D. V. Spicer, S. Lee, C. L. Pearce
    Pages 127-150
  5. Mammary Development, Carcinomas and Progesterone: Role of Wnt Signalling
    R. Lamb, H. Harrison, R. B. Clarke
    Pages 151-170
  6. Progesterone Signaling in Mammary Gland Development
    O. M. Conneely, B. Mulac-Jericevic, R. Arnett-Mansfield
    Pages 175-185
  7. Progesterone Receptor Isoforms in Normal and Malignant Breast
    P. A. Mote, J. D. Graham, C. L. Clarke
    Pages 190-207
  8. In Vivo Characterization of Progestins with Reduced Non-genomic Activity In Vitro
    C. Otto, B. Rohde-Schulz, G. Schwarz, I. Fuchs, M. Klewer, H. Altmann et al.
    Pages 208-235
  9. In Vitro and In Vivo Characterization of a Novel Nonsteroidal, Species-Specific Progesterone Receptor Modulator, PRA-910
    Z. Zhang, S. G. Lundeen, O. Slayden, Y. Zhu, J. Cohen, T. J. Berrodin et al.
    Pages 236-250

About these proceedings


Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21–23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed.


Breast Cancer Endocrinology Mammary Gland Pharmacology Progesterone Receptor Regulation tissue

Bibliographic information

  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-73492-5
  • Online ISBN 978-3-540-73493-2
  • Series Print ISSN 0947-6075