Therapeutic Antibodies

Editors:

ISBN: 978-3-540-73258-7 (Print) 978-3-540-73259-4 (Online)

Table of contents (15 chapters)

  1. Front Matter

    Pages i-xi

  2. Introduction

    1. No Access

      Book Chapter

      Pages 3-18

      Historical Development of Monoclonal Antibody Therapeutics

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      Book Chapter

      Pages 19-44

      Preclinical Safety Evaluation of Monoclonal Antibodies

  3. Molecular Developments in Antibody Production

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      Book Chapter

      Pages 47-68

      Engineering Antibodies for Stability and Efficient Folding

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      Book Chapter

      Pages 69-97

      Human Monoclonal Antibodies from Transgenic Mice

  4. Antibodies to Cytokines

    1. No Access

      Book Chapter

      Pages 101-129

      Anti-TNF Antibodies: Lessons from the Past, Roadmap for the Future

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      Book Chapter

      Pages 131-150

      Therapeutic Anti-VEGF Antibodies

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      Book Chapter

      Pages 151-160

      Humanized Antihuman IL-6 Receptor Antibody, Tocilizumab

  5. Antibodies to Cell Markers

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      Book Chapter

      Pages 163-181

      Anti-CD20Monoclonal Antibody in Rheumatoid Arthritis and Systemic Lupus Erythematosus

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      Book Chapter

      Pages 183-219

      Herceptin

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      Book Chapter

      Pages 221-236

      The Use of CD3-Specific Antibodies in Autoimmune Diabetes: A Step Toward the Induction of Immune Tolerance in the Clinic

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      Book Chapter

      Pages 237-256

      Monoclonal Antibody Therapy for Prostate Cancer

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      Book Chapter

      Pages 257-288

      Anti-IgE and Other Antibody Targets in Asthma

  6. Development of Antibody-Based Cellular and Molecular Therapies

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      Book Chapter

      Pages 291-328

      Cytokine, Chemokine, and Co-Stimulatory Fusion Proteins for the Immunotherapy of Solid Tumors

    2. No Access

      Book Chapter

      Pages 329-342

      The T-Body Approach: Redirecting T Cells with Antibody Specificity

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      Book Chapter

      Pages 343-373

      Intracellular Antibodies (Intrabodies) and Their Therapeutic Potential

  7. Back Matter

    Pages 375-380