Protein-Protein Interactions as New Drug Targets


ISBN: 978-3-540-72842-9 (Print) 978-3-540-72843-6 (Online)

Table of contents (20 chapters)

  1. Front Matter

    Pages i-xv

  2. Organization of Scaffolds

    1. Chapter

      Pages 3-14

      A-Kinase Anchoring Proteins as the Basis for cAMP Signaling

    2. Chapter

      Pages 15-37

      Arrestins as Multi-Functional Signaling Adaptors

    3. Chapter

      Pages 39-65

      Role of Ena/VASP Proteins in Homeostasis and Disease

    4. Chapter

      Pages 67-103

      Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy

    5. Chapter

      Pages 105-122

      Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox?

  3. Scaffolding Proteins and Cellular Signalling

    1. Chapter

      Pages 125-166

      PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases

    2. Chapter

      Pages 167-184

      G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains

    3. Chapter

      Pages 185-203

      Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design

    4. Chapter

      Pages 205-235

      Compartmentalised MAPK Pathways

    5. Chapter

      Pages 237-259

      Dynamic Protein Complexes Regulate NF-κB Signaling

    6. Chapter

      Pages 261-284

      An Oncogenic Hub: β-Catenin as a Molecular Target for Cancer Therapeutics

    7. Chapter

      Pages 285-298

      A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling

  4. Cell Type-Specific Anchoring

    1. Chapter

      Pages 301-325

      Scaffolding Proteins in Cardiac Myocytes

    2. Chapter

      Pages 327-363

      Molecular Architecture of Signal Complexes Regulating Immune Cell Function

    3. Chapter

      Pages 365-380

      Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework

  5. Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept

    1. Chapter

      Pages 383-405

      Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies

    2. Chapter

      Pages 407-429

      Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition

    3. Chapter

      Pages 431-460

      Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors

    4. Chapter

      Pages 461-482

      Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs

    5. Chapter

      Pages 483-503

      Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets

  6. Back Matter

    Pages 505-512