2007

Chromosomal Alterations

Methods, Results and Importance in Human Health

ISBN: 978-3-540-71413-2 (Print) 978-3-540-71414-9 (Online)

Table of contents (31 chapters)

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  1. Front Matter

    Pages i-xxiv

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    Book Chapter

    Pages 1-20

    Human Chromosomes: Structural and Functional Aspects

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    Book Chapter

    Pages 21-38

    DNA Lesions Induced by Ionizing Radiation

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    Book Chapter

    Pages 39-53

    Effects of Ultraviolet Radiation on DNA

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    Book Chapter

    Pages 55-65

    Double Strand Break Repair Mechanisms in Mammalian Cells

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    Book Chapter

    Pages 67-85

    Backup Pathways of Nonhomologous End Joining May Have a Dominant Role in the Formation of Chromosome Aberrations

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    Pages 87-98

    Targeted and Non-Targeted Induction of Chromosomal Rearrangements After Exposure to Ionizing Radiation

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    Book Chapter

    Pages 99-121

    DNA Methylation Damage: Formation, Repair and Biological Consequences

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    Book Chapter

    Pages 123-143

    Adducts, Sister-Chromatid Exchanges and Mutations Following Benzo[a]pyrene Exposure: a Review of Quantitative Data Followed by Some Considerations Regarding Risk

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    Book Chapter

    Pages 145-160

    Analysis of DNA Double-Strand Breaks by Means of γ-H2AX Foci

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    Pages 161-176

    Comet Assay

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    Book Chapter

    Pages 177-199

    Origin of Chromosome Aberrations: Mechanisms

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    Book Chapter

    Pages 201-209

    Chromatin Structure and the Formation of Chromosomal Alterations

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    Book Chapter

    Pages 211-224

    Role of Chromatin Structure and Activity in the Induction of Chromosomal Aberrations

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    Book Chapter

    Pages 225-240

    A Biomedical Perspective of Telomere Structure and Function

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    Book Chapter

    Pages 241-255

    Cytokinesis-Block Micronucleus Assay: a Comprehensive “Cytome” Approach for Measuring Chromosomal Instability, Mitotic Dysfunction and Cell Death Simultaneously in One Assay

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    Book Chapter

    Pages 257-270

    In Vivo Rodent Micronucleus Assay

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    Book Chapter

    Pages 271-283

    Sister-Chromatid Exchanges

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    Book Chapter

    Pages 285-299

    Fluorescence in Situ Hybridisation

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    Book Chapter

    Pages 301-314

    The CAB and S&S Systems, and an Approach Towards the Classification of Complex Chromosome Exchanges

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    Book Chapter

    Pages 315-324

    Aberration Patterns and Cell Cycle Progression Following Exposure of Lymphocytes to the Alkylating Agent Trenimon

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