Tissue-Specific Estrogen Action

Novel Mechanisms, Novel Ligands, Novel Therapies

  • Editors
  • K. S. Korach
  • T. Wintermantel
Conference proceedings

DOI: 10.1007/978-3-540-49548-2

Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2006/1)

Table of contents (10 papers)

  1. Front Matter
    Pages i-xv
  2. Interfering with the Dynamics of Estrogen Receptor-Regulated Transcription
    S. A. Johnsen, S. Kangaspeska, G. Reid, F. Gannon
    Pages 1-12
  3. Genetic Dissection of Estrogen Receptor Signaling In Vivo
    T. M. Wintermantel, J. Elzer, A. E. Herbison, K.-H. Fritzemeier, G. Schütz
    Pages 25-44
  4. Of Mice and Men: The Many Guises of Estrogens
    E. R. Simpson, M. E. Jones
    Pages 45-68
  5. Estradiol Action in Atherosclerosis and Reendothelialization
    J.- F. Arnal, H. Laurell, F. Lenfant, V. Douin-Echinard, L. Brouchet, P. Gourdy
    Pages 69-86
  6. Functional Effects and Molecular Mechanisms of Subtype-Selective ERα and ERβ Agonists in the Cardiovascular System
    P. A. Arias-Loza, V. Jazbutyte, K.-H. Fritzemeier, C. Hegele-Hartung, L. Neyses, G. Ertl et al.
    Pages 87-106
  7. The Role of ERα and ERβ in theProstate: Insights from Genetic Models and Isoform-Selective Ligands
    S. J. McPherson, S. J. Ellem, V. Patchev, K. H. Fritzemeier, G. P. Risbridger
    Pages 131-148
  8. Back Matter
    Pages 183-183

About these proceedings

Introduction

Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways mediated by these receptors warrant further research, even though in principle they appeared to represent the most immediate, seemingly simple signaling pathway from hormone (ligand) binding to gene expression changes. In nuclear receptor molecular biology, estrogen receptor research has additional unique facets: since the discovery of ethinyl estradiol by Inhoffen and Hohlweg in the laboratories of Schering AG in the 1930s—and therefore several decades longer than nuclear receptor - searchitself—estrogenreceptorshavebeentargetsofwidelyused,orally administered drugs. Thus, accumulating clinical experience on estrogen action in vivo helps to support the progress in molecular biological research.

Keywords

Cardiovascular Biology Endocrinology Molecular Medicine Pharmacology Steroids cell biology cells endothelium estrogen action estrogen receptor receptor signaling tissue

Bibliographic information

  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-49547-5
  • Online ISBN 978-3-540-49548-2
  • Series Print ISSN 0947-6075