PET Chemistry

The Driving Force in Molecular Imaging


ISBN: 978-3-540-32623-6 (Print) 978-3-540-49527-7 (Online)

Table of contents (13 chapters)

  1. Front Matter

    Pages I-XII

  2. Chapter

    Pages 1-13

    Molecular Imaging with PET — Open Questions?

  3. Chapter

    Pages 15-50

    Fluorine-18 Labeling Methods: Features and Possibilities of Basic Reactions

  4. Chapter

    Pages 51-78

    Fluorine-18 Labeling of Small Molecules: The Use of 18F-Labeled Aryl Fluorides Derived from No-Carrier-Added [18F]Fluoride as Labeling Precursors

  5. Chapter

    Pages 79-111

    Fluorine-18 Labeling of Peptides and Proteins

  6. Chapter

    Pages 113-157

    [18F]Fluoropyridines: From Conventional Radiotracers to the Labeling of Macromolecules Such as Proteins and Oligonucleotides

  7. Chapter

    Pages 159-181

    Production of Non-standard PET Radionuclides and the Application of Radiopharmaceuticals Labeled with these Nuclides

  8. Chapter

    Pages 183-213

    Carbon-11 Labeling Chemistry Based upon [11C]Methyl Iodide

  9. Chapter

    Pages 215-242

    68Ga-PET Radiopharmacy: A Generator-Based Alternative to 18F-Radiopharmacy

  10. Chapter

    Pages 243-269

    Microwaving in F-18 Chemistry: Quirks and Tweaks

  11. Chapter

    Pages 271-287

    Micro-reactors for PET Tracer Labeling

  12. Chapter

    Pages 289-316

    Synthesis Modules and Automation in F-18 Labeling

  13. Chapter

    Pages 317-327

    Pharmacological Prerequisites for PET Ligands and Practical Issues in Preclinical PET Research

  14. Chapter

    Pages 329-339

    Positron Emission Tomography Imaging as a Key Enabling Technology in Drug Development

  15. Back Matter

    Pages 341-345