PET Chemistry

The Driving Force in Molecular Imaging

  • P. A. Schubiger
  • L. Lehmann
  • M. Friebe
Conference proceedings

DOI: 10.1007/978-3-540-49527-7

Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 64)

Table of contents

  1. Front Matter
    Pages I-XII
  2. H. J. Wester, M. Schottelius
    Pages 79-111
  3. F. Wuest, M. Berndt, T. Kniess
    Pages 183-213
  4. S. Stone-Elander, N. Elander, J. -O. Thorell, A. Fredriksson
    Pages 243-269
  5. S. Y. Lu, V. W. Pike
    Pages 271-287
  6. Back Matter
    Pages 341-345

About these proceedings

Introduction

Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for speci?c e- point monitoring in modern drug development. PET (positron emitting tomography), a nuclear medical imaging modality, is ideally suited to produce three-dimensional images of various targets or processes. The rapidly increasing demand for highly selective probes for MI strongly pushes the development of new PET tracers and PET chemistry. ‘PET chemistry’ can be de?ned as the study of positron-emitting compounds regarding their synthesis, structure, composition, reactivity, nuclear properties and processes and their properties in natural and - natural environments. In practice PET chemistry is strongly in?uenced by the unique properties of the radioisotopes used (e. g. , half-life, che- cal reactivity, etc. ) and integrates scienti?c aspects of nuclear-, organic-, inorganic- and biochemistry.

Keywords

Base Biomedical Chemistry Molecular Imaging Nucleotide PET Tracer Radiochemistry jRadiolabeling positron emission tomography

Editors and affiliations

  • P. A. Schubiger
    • 1
  • L. Lehmann
    • 2
  • M. Friebe
    • 2
  1. 1.Animal Imaging Center — PET, Center for Radiopharmaceutical Science of ETH, PSI and USZETH Hönggerberg D-CHABZürichSwitzerland
  2. 2.Corporate ResearchSchering AGBerlinGermany

Bibliographic information

  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-32623-6
  • Online ISBN 978-3-540-49527-7
  • Series Print ISSN 0947-6075