GPCRs: From Deorphanization to Lead Structure Identification


ISBN: 978-3-540-48981-8 (Print) 978-3-540-48982-5 (Online)

Table of contents (12 chapters)

  1. Front Matter

    Pages i-xvii

  2. Chapter

    Pages 1-22

    G-Proteins and GPCRs: From the Beginning

  3. Chapter

    Pages 23-48

    Modeling GPCRs

  4. Chapter

    Pages 49-74

    QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications

  5. Chapter

    Pages 75-92

    Privileged Structures in GPCRs

  6. Chapter

    Pages 93-104

    Designing Compound Libraries Targeting GPCRs

  7. Chapter

    Pages 105-144

    Orphan Seven Transmembrane Receptor Screening

  8. Chapter

    Pages 145-162

    The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling

  9. Chapter

    Pages 163-186

    Deorphanization of G-Protein-Coupled Receptors

  10. Chapter

    Pages 187-210

    Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function and Their Potential as Drug Target

  11. Chapter

    Pages 211-228

    Modulation of GPCR Conformationsby Ligands, G-Proteins, and Arrestins

  12. Chapter

    Pages 229-248

    High Content Screening to Monitor G Protein-Coupled Receptor Internalisation

  13. Chapter

    Pages 249-266

    High-Throughput Lead Finding and Optimisation for GPCR Targets