Conditional Mutagenesis: An Approach to Disease Models

Editors:

ISBN: 978-3-540-35108-5 (Print) 978-3-540-35109-2 (Online)

Table of contents (21 chapters)

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  1. Front Matter

    Pages I-XI

  2. Tools for Conditional Mutagenesis

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-28

      Conditional Somatic Mutagenesis in the Mouse Using Site-Specific Recombinases

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      Book Chapter

      Pages 29-48

      Cre/loxP-Mediated Chromosome Engineering of the Mouse Genome

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      Book Chapter

      Pages 49-72

      Tetracycline-Controlled Genetic Switches

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      Book Chapter

      Pages 73-105

      Novel Gene Switches

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      Book Chapter

      Pages 107-128

      Improved Embryonic Stem Cell Technologies

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      Book Chapter

      Pages 129-147

      Gene Trap Mutagenesis

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      Book Chapter

      Pages 149-176

      RNA Interference in Mice

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      Book Chapter

      Pages 177-202

      Viral Vectors: A Wide Range of Choices and High Levels of Service

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      Book Chapter

      Pages 203-232

      Conditional Mutagenesis by Cell-Permeable Proteins: Potential, Limitations and Prospects

  3. Examples of Conditional Disease Models

    1. Front Matter

      Pages 233-233

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      Book Chapter

      Pages 235-262

      Analysis of Mouse Development with Conditional Mutagenesis

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      Book Chapter

      Pages 263-287

      Conditional Mouse Models of Cancer

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      Pages 289-314

      Conditional Mutagenesis Reveals Immunological Functions of Widely Expressed Genes: Activation Thresholds, Homeostatic Mechanisms and Disease Models

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      Book Chapter

      Pages 315-345

      Conditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity and Memory

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      Book Chapter

      Pages 347-363

      A Novel Conditional Knockout Strategy Applied to Serotonin Receptors

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      Book Chapter

      Pages 365-375

      Conditional Mouse Models for Friedreich Ataxia, a Neurodegenerative Disorder Associating Cardiomyopathy

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      Book Chapter

      Pages 377-405

      Animal Models in Cardiovascular Diseases: New Insights from Conditional Models

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      Book Chapter

      Pages 407-439

      Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders

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      Book Chapter

      Pages 441-468

      Conditional Mouse Models to Study Developmental and Pathophysiological Gene Function in Muscle

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      Book Chapter

      Pages 469-490

      Analysis of Calcium Channels by Conditional Mutagenesis

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      Book Chapter

      Pages 491-509

      Conditional Mutagenesis of G-Protein Coupled Receptors and G-Proteins

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