Systems Biology

Applications and Perspectives

  • P. Bringmann
  • E. C. Butcher
  • G. Parry
  • B. Weiss
Conference proceedings

DOI: 10.1007/978-3-540-31339-7

Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 61)

Table of contents (8 papers)

  1. Front Matter
    Pages I-XIII
  2. RNAi Applications in Target Validation
    A. Kourtidis, C. Eifert, D. S. Conklin
    Pages 1-21
  3. Does the Serum Peptidome Reveal Hemostatic Dysregulation?
    M. T. Davis, S. D. Patterson
    Pages 23-44
  4. Network Genomics
    T. E. Ideker
    Pages 89-115
  5. A Plea for More Theory in Molecular Biology
    O. Wolkenhauer, M. Mesarović, P. Wellstead
    Pages 117-137
  6. Applying a Causal Framework to System Modeling
    C. A. Lieu, K. O. Elliston
    Pages 139-152
  7. Back Matter
    Pages 173-177

About these proceedings

Introduction

Systems biology has emerged as a highly interdisciplinary ?eld that has created broad enthusiasm in the scienti?c community. Systems biology is in vogue because of its potential to revolutionize not only biology but also medicine. Developments are anticipated that will change how we think about disease and how we approach therapeutic intervention. Perhaps the boldest vision of this future is presented by Dr. Leroy Hood, President of the Institute for Systems Biology in Seattle. He has been a protagonist and the main driving force of the underlying concept. - cording to Dr. Hood, systems biology will make possible a new era of medical care comprising predictive, preventive, personalized and part- ipatory (P4) medicine. While this vision appears futuristic, it has enticed both academic scienti?c communities and pharmaceutical industry R&D organizations. Systems biology ultimately attempts to understand biological s- tems at the molecular level. Examples of such systems are subcellular regulatory circuits with all their components, cells, organs, as well as - tire organisms. Over the past decade, technologies have been developed that enable systems-level interrogations, e.g., gene expression pro?ling, proteomics, and metabonomics, to name a few. Scientists have used such platforms to accumulate a tremendous amount of data. Although we have learned a great deal by collecting such detailed information, it seems our understanding has not similarly increased.

Keywords

Drug Discovery and Development biology cancer cell cell biology drug design genome genomics molecular biology proteomics systems biology

Editors and affiliations

  • P. Bringmann
    • 1
  • E. C. Butcher
    • 2
  • G. Parry
    • 3
  • B. Weiss
    • 4
  1. 1.Systems BiologyBerlex BiocsciencesRichmondUSA
  2. 2.Department of PathologyStanford University Medical CenterStanfordUSA
  3. 3.Berlex BiosciencesRichmondUSA
  4. 4.Genomics & BioinformaticsSchering AGBerlinGermany

Bibliographic information

  • Copyright Information Springer-Verlag Berlin Heidelberg 2007
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-31338-0
  • Online ISBN 978-3-540-31339-7
  • Series Print ISSN 0947-6075