Dental Stem Cells

1. Front Matter

   Pages i-xiii

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2. Dental and Craniofacial Tissue Stem Cells: Sources and Tissue Engineering Applications

   • Paul R. Cooper

   Pages 1-27

3. Immunomodulatory Properties of Stem Cells Derived from Dental Tissues

   • Pakize Neslihan Taşlı, Safa Aydın, Fikrettin Şahin

   Pages 29-45

4. miRNA Regulation in Dental Stem Cells: From Development to Terminal Differentiation

   • Sukru Gulluoglu, Emre Can Tuysuz, Omer Faruk Bayrak

   Pages 47-67

5. Signaling Pathways in Dental Stem Cells During Their Maintenance and Differentiation

   • Genxia Liu, Shu Ma, Yixiang Zhou, Yadie Lu, Lin Jin, Zilu Wang et al.

   Pages 69-92

6. Genetically Engineered Dental Stem Cells for Regenerative Medicine

   • Valeriya V. Solovyeva, Andrey P. Kiyasov, Albert A. Rizvanov

   Pages 93-107

7. Dental Stem Cells vs. Other Mesenchymal Stem Cells: Their Pluripotency and Role in Regenerative Medicine

   • Selami Demirci, Ayşegül Doğan, Fikrettin Şahin

   Pages 109-124

8. Induced Pluripotent Stem Cells Derived from Dental Stem Cells: A New Tool for Cellular Therapy

   • Irina Kerkis, Cristiane V. Wenceslau, Celine Pompeia

   Pages 125-141

9. Dental Stem Cells in Oral, Maxillofacial and Craniofacial Regeneration

   • Arash Khojasteh, Pantea Nazeman, Maryam Rezai Rad

   Pages 143-165

10. Dental Stem Cells: Possibility for Generation of a Bio-tooth

    • Sema S. Hakki, Erdal Karaoz

    Pages 167-196

11. Dental Stem Cells for Bone Tissue Engineering

    • Zhipeng Fan, Xiao Lin

    Pages 197-216

12. Dental Stem Cells: Their Potential in Neurogenesis and Angiogenesis

    • Annelies Bronckaers, Esther Wolfs, Jessica Ratajczak, Petra Hilkens, Pascal Gervois, Ivo Lambrichts et al.

    Pages 217-241

13. Dental Stem Cell Differentiation Toward Endodermal Cell Lineages: Approaches to Control Hepatocytes and Beta Cell Transformation

    • Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Prakash Nathan, Sabri Musa, Noor Hayaty Abu Kasim

    Pages 243-268

14. Dental Stem Cells in Regenerative Medicine: Clinical and Pre-clinical Attempts

    • Ferro Federico, Renza Spelat

    Pages 269-287

15. Future Perspectives in Dental Stem Cell Engineering and the Ethical Considerations

    • Naohisa Wada, Atsushi Tomokiyo, Hidefumi Maeda

    Pages 289-307

16. Back Matter

    Pages 309-317

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This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field.  The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells. 


Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer’s Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine. 

• bone tissue
• craniofacial regeneration
• mesenchymal progenitor cells
• bio-tooth
• angiogenesis

• Yeditepe University, Genetics and Bioengineering Department, Istanbul, Turkey

  Fikrettin Şahin, Ayşegül Doğan

• Yeditepe University, Genetics and Bioengineering Department, ISTANBUL, Turkey

  Selami Demirci

Fikrettin Şahin received his PhD from the College of Food, Agricultural and Environmental Sciences, The Ohio State University, Columbus, Ohio. After completing his postdoctoral research at the same university and at the Pest Management Research Centre of Agriculture and Agri-Food Canada, he worked as an assistant professor in the Department of Plant Pathology, Ataturk University, in Erzurum, Turkey. Dr. Sahin is now a professor and chair of the Department of Genetics and Bioengineering, Yeditepe University, İstanbul, Turkey. He is on the advisory board of several journals, a member of the Technology and Inonvation Support Programme (TEYDEP), a principal member of The Turkish Academy of Sciences, and many other prestigious scientific committees and initiatives. Prolifically and internationally published, Dr. Sahin’s research focuses on dental stem cells in the contexts of isolation, maintenance, differentiation and possible use for particular regenerative approaches. His other research areas include  molecular microbiology, phytopathology, stem cell and gene therapy, and cancer.   


Ayşegül Doğan received her PhD from Yeditepe University in Istanbul, Turkey, where she is a postdoctoral researcher in the Department of Genetics and Bioengineering. She works with the Gene and Cell Therapy group at the University’s Molecular Diagnostic Laboratory, and is a member of stem cell and cellular therapy societies in Turkey. Her research focuses on mesenchymal stem cells, gene and cell therapy, cancer and wound healing. Dr. Doğan is currently working with dental stem cells obtained from wisdom teeth of young adults and the potential use of these cells in gene and stem cell therapy applications. 

Selami Demirci received his PhD from the department of Genetics and Bioengineering at the University of Yeditepe in Istanbul, Turkey. He is currently a Research fellow at the same department. Dr. Demirci isa member of the Stem Cell and Cellular Therapies Society, Turkey, and has completed several projects on dental stem cell maintenance and differentiation towards desired cell lineages for a particular regeneration approaches. His ongoing studies includes gene functions in stem cell, wound healing and regenerative medicine.   

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