Current Advances in Osteosarcoma


ISBN: 978-3-319-04842-0 (Print) 978-3-319-04843-7 (Online)

Table of contents (20 chapters)

  1. Front Matter

    Pages i-xii

  2. Chapter

    Pages 1-30

    Historical Perspective on the Introduction and Use of Chemotherapy for the Treatment of Osteosarcoma

  3. Novel Therapeutic Targets

    1. Front Matter

      Pages 31-31

    2. Chapter

      Pages 33-45

      Wnt Signaling in Osteosarcoma

    3. Chapter

      Pages 47-66

      Receptor Tyrosine Kinases in Osteosarcoma: Not Just the Usual Suspects

    4. Chapter

      Pages 67-92

      Understanding the Role of Notch in Osteosarcoma

    5. Chapter

      Pages 93-118

      Developmental Pathways Hijacked by Osteosarcoma

    6. Chapter

      Pages 119-127

      MicroRNAs in Osteosarcomagenesis

    7. Chapter

      Pages 129-145

      RECQ DNA Helicases and Osteosarcoma

    8. Chapter

      Pages 147-160

      Autophagy in Osteosarcoma

    9. Chapter

      Pages 161-177

      HER-2 Involvement in Osteosarcoma

  4. Tumor Microenvironment

    1. Front Matter

      Pages 179-179

    2. Chapter

      Pages 181-201

      Role of Ezrin in Osteosarcoma Metastasis

    3. Chapter

      Pages 203-217

      Participation of the Fas/FasL Signaling Pathway and the Lung Microenvironment in the Development of Osteosarcoma Lung Metastases

  5. Unique Osteosarcoma Models

    1. Front Matter

      Pages 219-219

    2. Chapter

      Pages 221-236

      Zebrafish as a Model for Human Osteosarcoma

    3. Chapter

      Pages 237-256

      Using Canine Osteosarcoma as a Model to Assess Efficacy of Novel Therapies: Can Old Dogs Teach Us New Tricks?

  6. Novel Therapeutic Approaches Based on Biology: Tumor Targeted Therapy

    1. Front Matter

      Pages 257-257

    2. Chapter

      Pages 259-283

      Oncolytic Viruses for Potential Osteosarcoma Therapy

    3. Chapter

      Pages 285-289

      IL-11Rα: A Novel Target for the Treatment of Osteosarcoma

    4. Chapter

      Pages 291-304

      Bone-Seeking Radiopharmaceuticals as Targeted Agents of Osteosarcoma: Samarium-153-EDTMP and Radium-223

  7. Novel Therapeutic Approaches Based on Biology: Immunotherapy

    1. Front Matter

      Pages 305-305

    2. Chapter

      Pages 307-321

      Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma

    3. Chapter

      Pages 323-340

      Genetically Modified T-Cell Therapy for Osteosarcoma

    4. Chapter

      Pages 341-353

      Natural Killer Cells for Osteosarcoma

  8. Chapter

    Pages E1-E1


  9. Back Matter

    Pages 355-359