Animal Models in Diabetes Research

Editors:

ISBN: 978-1-62703-067-0 (Print) 978-1-62703-068-7 (Online)

Table of contents (21 protocols)

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  1. Front Matter

    Pages i-xi

  2. Rodent Models of Type 1 Diabetes

    1. Front Matter

      Pages 1-1

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      Pages 3-16

      The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes

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      Pages 17-29

      Assessment of Diabetic Nephropathy in the Akita Mouse

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      Pages 31-44

      The BB Rat as a Model of Human Type 1 Diabetes

  3. Rodent Models of Type 2 Diabetes

    1. Front Matter

      Pages 45-45

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      Pages 47-57

      Diabetes in Mice with Monogenic Obesity: The db/db Mouse and Its Use in the Study of Cardiac Consequences

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      Pages 59-73

      Pathophysiology and Genetics of Obesity and Diabetes in the New Zealand Obese Mouse: A Model of the Human Metabolic Syndrome

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      Pages 75-87

      The TALLYHO Mouse as a Model of Human Type 2 Diabetes

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      Pages 89-102

      Diet-Induced Diabetes in the Sand Rat (Psammomys obesus)

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      Pages 103-123

      Diabetes in Zucker Diabetic Fatty Rat

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      Pages 125-159

      The GK Rat: A Prototype for the Study of Non-overweight Type 2 Diabetes

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      Pages 161-174

      Experimentally Induced Rodent Models of Type 2 Diabetes

  4. Other Species

    1. Front Matter

      Pages 175-175

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      Pages 177-185

      Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates

  5. General Methodology

    1. Front Matter

      Pages 187-187

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      Pages 189-201

      Determination of Beta-Cell Function: Insulin Secretion of Isolated Islets

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      Pages 203-217

      Determination of Beta-Cell Function: Ion Channel Function in Beta Cells

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      Pages 219-228

      Measurement of Glucose Homeostasis In Vivo: Glucose and Insulin Tolerance Tests

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      Pages 229-253

      Measurement of Glucose Homeostasis In Vivo: Combination of Tracers and Clamp Techniques

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      Pages 255-263

      Measurement of Insulin Sensitivity in Skeletal Muscle In Vitro

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      Pages 265-274

      Beta-Cell Autoimmunity

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      Pages 275-289

      Positional Cloning of Diabetes Genes

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      Pages 291-302

      Retinal Digest Preparation: A Method to Study Diabetic Retinopathy

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      Pages 303-315

      Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration

  6. Back Matter

    Pages 323-325

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