Protein Kinase C in Cancer Signaling and Therapy

Editors:

ISBN: 978-1-60761-542-2 (Print) 978-1-60761-543-9 (Online)

Table of contents (23 chapters)

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  1. Front Matter

    Pages i-xiv

  2. Regulation of PKC Isozyme Function: From Genes to Biochemistry

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-8

      Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective

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      Book Chapter

      Pages 9-23

      Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids

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      Pages 25-53

      Phorbol Esters and Diacylglycerol: The PKC Activators

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      Pages 55-78

      Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals

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      Book Chapter

      Pages 79-103

      Regulation of PKC by Protein–Protein Interactions in Cancer

  3. PKC Isozymes in the Control of Cell Function

    1. Front Matter

      Pages 106-106

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      Book Chapter

      Pages 107-115

      Introduction: PKC Isozymes in the Control of Cell Function

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      Book Chapter

      Pages 117-154

      Regulation and Function of Protein Kinase D Signaling

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      Pages 155-188

      PKC and Control of the Cell Cycle

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      Pages 189-222

      PKC and the Control of Apoptosis

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      Pages 223-244

      Atypical PKCs, NF-κB, and Inflammation

  4. PKC Isozymes in Cancer

    1. Front Matter

      Pages 246-246

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      Book Chapter

      Pages 247-251

      Introduction: PKC and Cancer

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      Book Chapter

      Pages 253-265

      Protein Kinase C, p53, and DNA Damage

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      Book Chapter

      Pages 267-286

      PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways

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      Book Chapter

      Pages 287-303

      PKC–PKD Interplay in Cancer

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      Book Chapter

      Pages 305-321

      Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer

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      Book Chapter

      Pages 323-345

      PKC Isozymes and Skin Cancer

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      Book Chapter

      Pages 347-360

      PKC and Breast Cancer

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      Book Chapter

      Pages 361-378

      PKC and Prostate Cancer

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      Book Chapter

      Pages 379-399

      Protein Kinase C and Lung Cancer

  5. PKC Isozymes as Targets for Cancer Therapy

    1. Front Matter

      Pages 402-402

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      Book Chapter

      Pages 403-407

      Introduction

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