Membrane Receptors, Channels and Transporters in Pulmonary Circulation

  • Jason X. -J. Yuan
  • Jeremy P. T. Ward
Conference proceedings

DOI: 10.1007/978-1-60761-500-2

Part of the Advances in Experimental Medicine and Biology book series (volume 661)

Table of contents (31 papers)

  1. Front Matter
    Pages i-xvi
  2. Ion Channels in the Pulmonary Vasculature: Basics and New Findings

    1. Front Matter
      Pages 1-1
    2. E. Kenneth Weir, Jésus A. Cabrera, Saswati Mahapatra, Douglas A. Peterson, Zhigang Hong
      Pages 3-14
    3. Abigail S. Forrest, Jeff E. Angermann, Rajesh Raghunathan, Catherine Lachendro, Iain A. Greenwood, Normand Leblanc
      Pages 31-55
    4. Michael J. Sanderson, Yan Bai, Jose Perez-Zoghbi
      Pages 77-96
  3. TRP Channels in the Pulmonary Vasculature: Basics and New Findings

    1. Front Matter
      Pages 98-98
    2. Michael Y. Song, Jason X.-J. Yuan
      Pages 99-108
    3. Lih Chyuan Ng, Judith A. Airey, Joseph R. Hume
      Pages 123-135
    4. Claudie M. Hecquet, Gias U. Ahmmed, Asrar B. Malik
      Pages 155-167
  4. Pathogenic Role of Ion Channels in Pulmonary Vascular Disease

  5. Receptors and Signaling Cascades in Pulmonary Arterial Hypertension

    1. Front Matter
      Pages 250-250

About these proceedings

Introduction

Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.

Keywords

Calcium cell circulation hypertension membrane physiology protein regulation vascular disease

Editors and affiliations

  • Jason X. -J. Yuan
    • 1
  • Jeremy P. T. Ward
    • 2
  1. 1.Departments of Medicine and PharmacologyUniversity of Illinois at ChicagoChicagoUSA
  2. 2.Guy’s Hospital Campus, Dept. PhysiologyKing’s College LondonLondonUnited Kingdom

Bibliographic information

  • Copyright Information Humana Press 2010
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-60761-499-9
  • Online ISBN 978-1-60761-500-2
  • Series Print ISSN 0065-2598