Multi-Drug Resistance in Cancer

Editors:

ISBN: 978-1-60761-415-9 (Print) 978-1-60761-416-6 (Online)

Table of contents (21 protocols)

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  1. Front Matter

    Pages i-ix

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    Pages 1-14

    Multidrug Resistance in Cancer

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    Pages 15-31

    Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets

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    Pages 33-45

    Studying Drug Resistance Using Genetically Engineered Mouse Models for Breast Cancer

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    Pages 47-76

    Mechanisms of Multidrug Resistance in Cancer

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    Pages 77-93

    Molecular Mechanisms of Drug Resistance in Single-Step and Multi-Step Drug-Selected Cancer Cells

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    Pages 95-121

    Pharmacogenetics of ATP-Binding Cassette Transporters and Clinical Implications

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    Pages 123-139

    Flow Cytometric Evaluation of Multidrug Resistance Proteins

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    Pages 141-181

    Targeted Chemotherapy in Drug-Resistant Tumors, Noninvasive Imaging of P-Glycoprotein-Mediated Functional Transport in Cancer, and Emerging Role of Pgp in Neurodegenerative Diseases

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    Pages 183-198

    Epigenetic Regulation of Multidrug Resistance 1 Gene Expression: Profiling CpG Methylation Status Using Bisulphite Sequencing

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    Pages 199-222

    Expression and Function of P-Glycoprotein in Normal Tissues: Effect on Pharmacokinetics

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    Pages 223-249

    Molecular Mechanism of ATP-Dependent Solute Transport by Multidrug Resistance-Associated Protein 1

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    Pages 251-290

    Impact of Breast Cancer Resistance Protein on Cancer Treatment Outcomes

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    Pages 291-323

    Drug Ratio-Dependent Antagonism: A New Category of Multidrug Resistance and Strategies for Its Circumvention

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    Pages 325-340

    Reversing Agents for ATP-Binding Cassette Drug Transporters

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    Pages 341-358

    Overcoming Multidrug Resistance in Cancer: Clinical Studies of P-Glycoprotein Inhibitors

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    Pages 359-384

    Pharmacokinetic and Pharmacodynamic Implications of P-Glycoprotein Modulation

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    Pages 385-403

    Examination of CYP3A and P-Glycoprotein-Mediated Drug–Drug Interactions Using Animal Models

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    Pages 405-432

    Generating Inhibitors of P-Glycoprotein: Where to, Now?

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    Pages 433-446

    Immunosuppressors as Multidrug Resistance Reversal Agents

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    Pages 447-465

    Overcoming Multidrug Resistance by RNA Interference

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