Immunotoxicity Testing

Methods and Protocols

Editors:

ISBN: 978-1-60761-400-5 (Print) 978-1-60761-401-2 (Online)

Table of contents (26 protocols)

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  1. Front Matter

    Pages i-x

  2. Introduction

    1. Front Matter

      Pages 1-1

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      Pages 3-13

      Immunotoxicology Testing: Past and Future

  3. Overview and Health-Risk Considerations

    1. Front Matter

      Pages 16-16

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      Pages 17-25

      Developmental Immunotoxicity (DIT): The Why, When, and How of DIT Testing

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      Pages 27-37

      An In Vivo Tiered Approach to Test Immunosensitization by Low Molecular Weight Compounds

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      Pages 39-51

      Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing

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      Pages 53-73

      Markers of Inflammation

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      Pages 75-94

      Evaluating Macrophages in Immunotoxicity Testing

  4. Immunotoxicity and Host Resistance Models

    1. Front Matter

      Pages 96-96

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      Pages 97-108

      Host Resistance Assays Including Bacterial Challenge Models

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      Pages 109-117

      Viral Host Resistance Studies

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      Pages 119-141

      Parasite Challenge as Host Resistance Models for Immunotoxicity Testing

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      Pages 143-155

      Tumor Challenges in Immunotoxicity Testing

  5. Testing Protocols in Rodents and Other Laboratory Animals

    1. Front Matter

      Pages 158-158

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      Pages 159-171

      The T-Dependent Antibody Response to Keyhole Limpet Hemocyanin in Rodents

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      Pages 173-184

      The Sheep Erythrocyte T-Dependent Antibody Response (TDAR)

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      Pages 185-194

      The Delayed Type Hypersensitivity Assay Using Protein and Xenogeneic Cell Antigens

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      Pages 195-205

      The Cytotoxic T Lymphocyte Assay for Evaluating Cell-Mediated Immune Function

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      Pages 207-219

      NK Cell Assays in Immunotoxicity Testing

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      Pages 221-231

      The Local Lymph Node Assay and Skin Sensitization Testing

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      Pages 233-239

      Use of Contact Hypersensitivity in Immunotoxicity Testing

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      Pages 241-257

      Evaluation of Apoptosis in Immunotoxicity Testing

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      Pages 259-281

      Dendritic Cells in Immunotoxicity Testing

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      Pages 283-302

      Evaluating Cytokines in Immunotoxicity Testing

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