New Strategies in Stroke Intervention

Ionic Transporters, Pumps, and New Channels


ISBN: 978-1-60761-279-7 (Print) 978-1-60761-280-3 (Online)

Table of contents (13 chapters)

  1. Front Matter

    Pages i-xv

  2. Chapter

    Pages 1-11

    Basis of Ionic Dysregulation in Cerebral Ischemia

  3. Chapter

    Pages 13-25

    Why have Ionotropic and Metabotropic Glutamate Antagonists Failed in Stroke Therapy?

  4. Chapter

    Pages 27-45

    Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia

  5. Chapter

    Pages 47-64

    Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke

  6. Chapter

    Pages 65-87

    The Na + /Ca 2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia

  7. Chapter

    Pages 89-111

    The “Loop” Diuretic Drug Bumetanide-Sensitive Na + -K + -Cl - Cotransporter in Cerebral Ischemia

  8. Chapter

    Pages 113-128

    The Na + /H + Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia

  9. Chapter

    Pages 129-151

    The Na + /K + -ATPase as a Drug Target for Ischemic Stroke

  10. Chapter

    Pages 153-173

    Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment

  11. Chapter

    Pages 175-188

    Role of TRPM7 in Ischemic CNS Injury

  12. Chapter

    Pages 189-209

    Subtypes of Voltage-Gated Ca 2+ Channels and Ischemic Brain Injury

  13. Chapter

    Pages 211-224

    The Diverse Roles of K + Channels in Brain Ischemia

  14. Chapter

    Pages 225-249

    Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke

  15. Back Matter

    Pages 251-254