Mouse Models for Drug Discovery

Methods and Protocols

Editors:

ISBN: 978-1-60761-057-1 (Print) 978-1-60761-058-8 (Online)

Table of contents (24 protocols)

previous Page of 2
  1. Front Matter

    Pages i-xii

  2. No Access

    Book Protocol

    Pages 1-21

    Improving Toxicity Screening and Drug Development by Using Genetically Defined Strains

  3. No Access

    Book Protocol

    Pages 23-36

    The Sophisticated Mouse: Protecting a Precious Reagent

  4. No Access

    Book Protocol

    Pages 37-54

    Genetically Engineered Mouse Models in Drug Discovery Research

  5. No Access

    Book Protocol

    Pages 55-77

    Engineering the Mouse Genome to Model Human Disease for Drug Discovery

  6. No Access

    Book Protocol

    Pages 79-92

    Profiling of Drug Action Using Reporter Mice and Molecular Imaging

  7. No Access

    Book Protocol

    Pages 93-104

    Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies

  8. No Access

    Book Protocol

    Pages 105-117

    Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease

  9. No Access

    Book Protocol

    Pages 119-134

    Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans

  10. No Access

    Book Protocol

    Pages 135-155

    Mouse Models of Type II Diabetes Mellitus in Drug Discovery

  11. No Access

    Book Protocol

    Pages 157-179

    Cholesterol Absorption and Metabolism

  12. No Access

    Book Protocol

    Pages 181-192

    Collagen-Induced Arthritis in Mice

  13. No Access

    Book Protocol

    Pages 193-213

    Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening

  14. No Access

    Book Protocol

    Pages 215-233

    Models of Metastasis in Drug Discovery

  15. No Access

    Book Protocol

    Pages 235-252

    Methods for Evaluating Effects of an Irinotecan + 5-Fluorouracil/Leucovorin (IFL) Regimen in an Orthotopic Metastatic Colorectal Cancer Model Utilizing In Vivo Bioluminescence Imaging

  16. No Access

    Book Protocol

    Pages 253-266

    CML Mouse Model in Translational Research

  17. No Access

    Book Protocol

    Pages 267-282

    Mouse Models for Studying Depression-Like States and Antidepressant Drugs

  18. No Access

    Book Protocol

    Pages 283-298

    Virus-Delivered RNA Interference in Mouse Brain to Study Addiction-Related Behaviors

  19. No Access

    Book Protocol

    Pages 299-321

    Experimental Models of Anxiety for Drug Discovery and Brain Research

  20. No Access

    Book Protocol

    Pages 323-345

    Mouse Models of Neurodegenerative Diseases: Criteria and General Methodology

  21. No Access

    Book Protocol

    Pages 347-393

    Neuromuscular Disease Models and Analysis

previous Page of 2