Inflammation and Cancer

Methods and Protocols: Volume 2: Molecular Analysis and Pathways

Editors:

ISBN: 978-1-60327-529-3 (Print) 978-1-60327-530-9 (Online)

Table of contents (22 protocols)

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  1. Front Matter

    Pages i-xv

  2. Crossroads of Inflammation and Cancer: Molecular Aspects

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      Pages 3-14

      Immunohistochemical Analysis of 8-Nitroguanine, A Nitrative DNA Lesion, in Relation to Inflammation-Associated Carcinogenesis

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      Pages 15-28

      Molecular Analysis of Genetic Instability Caused by Chronic Inflammation

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      Pages 29-37

      Obesity Provides a Permissive Milieu in Inflammation-Associated Carcinogenesis: Analysis of Insulin and IGF Pathways

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      Pages 39-54

      Detecting and Modulating the NF-kB Activity in Human Immune Cells: Generation of Human Cell Lines with Altered Levels of NF-κB

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      Pages 55-69

      Inflammation-Related Aberrant Patterns of DNA Methylation: Detection and Role in Epigenetic Deregulation of Cancer Cell Transcriptome

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      Pages 71-98

      cDNA Microarray Analysis of Inflammatory Breast Cancer Signatures

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      Pages 99-117

      Analysis of the TLR/NF-κB Pathway in Antigen-Presenting Cells in Malignancies Promoted by Inflammation

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      Pages 119-156

      Induced Nitric Oxide Synthase as a Major Player in the Oncogenic Transformation of Inflamed Tissue

  3. Molecular and Cellular Approaches to Diagnostics and Drug Target Discovery In Inflammation-Related Oncogenesis

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      Pages 159-167

      Development of a Cell-Based Assay to Quantify the Inflammatory Potential of Test Substances and Screen Compound Libraries for Anti-cancer Drug Candidates in a High-Throughput Format

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      Pages 169-207

      The NF-κB Transcription Factor Pathway as a Therapeutic Target in Cancer: Methods for Detection of NF-κB Activity

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      Pages 209-232

      Inhibiting Proinflammatory NF-κB Signaling Using Cell-Penetrating NEMO Binding Domain Peptides

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      Pages 233-248

      Quantitative Measurement of Cytokine Expression in Synoviocytes Derived from Rheumatoid Arthritis Patients

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      Pages 249-264

      Molecular Characterization of Inflammation-Induced JNK/c-Jun Signaling Pathway in Connection with Tumorigenesis

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      Pages 265-278

      Molecular Characterization of STAT Signaling in Inflammation and Tumorigenesis

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      Pages 279-293

      Inflammation and Tumor Progression: A Lesson from TNF-α-Dependent FAK Signaling in Cholangiocarcinoma

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      Pages 295-307

      Cyclooxygenase Inhibitors Induce Colon Cancer Cell Apoptosis Via PPARδ → 14-3-3ε Pathway

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      Pages 309-323

      PPARβ/δ Agonist Increases the Expression of PGE2 Receptor Subtype EP4 in Human Lung Carcinoma Cells

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      Pages 325-332

      Investigating Macrophage and Malignant Cell Interactions In Vitro

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      Pages 333-353

      Cellular Magnetic Resonance Imaging Using Superparamagnetic Anionic Iron Oxide Nanoparticles: Applications to In Vivo Trafficking of Lymphocytes and Cell-Based Anticancer Therapy

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      Pages 355-363

      Application of Phage Display to Discovery of Tumor-Specific Homing Peptides: Developing Strategies for Therapy and Molecular Imaging of Cancer

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