2007

Introduction to Systems Biology

Editors:

ISBN: 978-1-58829-706-8 (Print) 978-1-59745-531-2 (Online)

Table of contents (25 chapters)

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  1. Front Matter

    Pages i-xvi

  2. Introduction

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-13

      Scientific Challenges in Systems Biology

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      Book Chapter

      Pages 14-36

      Bringing Genomes to Life: The Use of Genome-Scale In Silico Models

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      Book Chapter

      Pages 37-66

      From Gene Expression to Metabolic Fluxes

  3. Experimental Techniques for Systems Biology

    1. Front Matter

      Pages 67-67

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      Book Chapter

      Pages 69-84

      Handling and Interpreting Gene Groups

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      Book Chapter

      Pages 85-105

      The Dynamic Transcriptome of Mice

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      Book Chapter

      Pages 106-123

      Dissecting Transcriptional Control Networks

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      Book Chapter

      Pages 124-146

      Reconstruction and Structural Analysis of Metabolic and Regulatory Networks

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      Book Chapter

      Pages 147-159

      Cross-Species Comparison Using Expression Data

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      Book Chapter

      Pages 160-182

      Methods for Protein-Protein Interaction Analysis

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      Book Chapter

      Pages 183-195

      Genome-Scale Assessment of Phenotypic Changes During Adaptive Evolution

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      Book Chapter

      Pages 196-214

      Location Proteomics

  4. Theoretical and Modeling Techniques

    1. Front Matter

      Pages 215-215

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      Book Chapter

      Pages 217-241

      Reconstructing Transcriptional Networks Using Gene Expression Profiling and Bayesian State-Space Models

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      Book Chapter

      Pages 242-260

      Modeling Spatiotemporal Dynamics of Multicellular Signaling

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      Book Chapter

      Pages 261-281

      Kinetics of Dimension-Restricted Conditions

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      Book Chapter

      Pages 282-299

      Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction

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      Book Chapter

      Pages 300-318

      Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space

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      Book Chapter

      Pages 319-335

      Dynamic Instabilities Within Living Neutrophils

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      Book Chapter

      Pages 336-371

      Efficiency, Robustness, and Stochasticity of Gene Regulatory Networks in Systems Biology: λ Switch as a Working Example

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      Book Chapter

      Pages 372-392

      Applications, Representation, and Management of Signaling Pathway Information: Introduction to the SigPath Project

  5. Methods and Software Platforms for Systems Biology

    1. Front Matter

      Pages 393-393

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      Book Chapter

      Pages 395-421

      SBML Models and MathSBML

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