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Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy

  • Book
  • © 2008

Overview

Editors:
  1. Benjamin Bonavida

    1. University of California at Los Angeles, Los Angeles, USA

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  • The first volume to compile studies on tumor cell sensitization
  • Useful for students, scientists, clinicians and pharmaceutical companies
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xxi
    Download chapter PDF

  2. Sensitization via Membrane-Bound Receptors

    1. Sensitization of Epithelial Cancer Cells with Human Monoclonal Antibodies

      • H. Peter Vollmers, Stephanie Brändlein
      Pages 3-11

    2. Targeting the Transferrin Receptor to Overcome Resistance to Anti-Cancer Agents

      • Tracy R. Daniels, Isabel I. Neacato, Gustavo Helguera, Manuel L. Penichet
      Pages 13-27

    3. Chemo-Immunosensitization of Resistant B-NHL as a Result of Rituximab (anti-CD20 mAb)-Mediated Inhibition of Cell Survival Signaling Pathways

      • Benjamin Bonavida, Ali R. Jazirehi, Mario I. Vega, Sara Huerta-Yepez, Kazuo Umezawa, Eriko Suzuki
      Pages 29-39

    4. Agents that Regulate DR5 and Sensitivity to TRAIL

      • Tatsushi Yoshida, Toshiyuki Sakai
      Pages 41-49

    5. Proteasome Inhibition: Potential for Sensitization of Immune Effector Mechanisms in Cancer

      • Milad Motarjemi, William H. D. Hallett, Minghui Li, William J. Murphy
      Pages 51-60

  3. Sensitization via Inhibition of Cell Survival Pathways (Excluding Apoptotic Signaling Pathways)

    1. Angiogenesis Inhibitors as Enabling Agents for the Chemotherapeutic Treatment of Metastatic Disease

      • Giulio Francia, Urban Emmenegger, Robert S. Kerbel
      Pages 63-80

    2. Targeting Survival Cascades Induced by Activation of Ras/Raf/MEK/ERK and PI3K/Akt Pathways to Sensitize Cancer Cells to Therapy

      • James A. McCubrey, Richard A. Franklin, Fred E. Bertrand, Jackson R. Taylor, William H. Chappell, Melissa L. Midgett et al.
      Pages 81-114

    3. Histone Deacetylase Inhibitors and Anticancer Activity

      • Roberto R. Rosato, Steven Grant
      Pages 115-131

    4. Eicosanoids and Resistance of Cancer Cells to Chemotherapeutic Agents

      • Andrey Sorokin
      Pages 133-156

  4. Sensitization via Transcription Factors

    1. The RKIP and STAT3 Axis in Cancer Chemotherapy: Opposites Attract

      • Devasis Chatterjee, Edmond Sabo, Murray B. Resnick, Kam C. Yeung, Y. Eugene Chin
      Pages 159-174

    2. Targeting Transcription Factors with Decoy Oligonucleotides: Modulation of the Expression of Genes Involved in Chemotherapy Resistance of Tumor Cells

      • Roberto Gambari
      Pages 175-187

    3. p53 Inhibitors as Cancer Sensitizing Agents

      • Flavio Maina, Rosanna Dono
      Pages 189-202

    4. Nitric Oxide—Induced Immunosensitization to Apoptosis by Fas-L and TRAIL

      • Benjamin Bonavida, Sara Huerta-Yepez, Mario I. Vega, Demetrios A. Spandidos, Stravoula Baritaki
      Pages 203-210

    5. Natural Agents That Can Sensitize Tumor Cells to Chemotherapy and Radiation Therapy

      • Ganesh Jagetia, Sunil Krishnan Krishnan, Bharat B. Aggarwal
      Pages 211-240

  5. Sensitization via Targeting Apoptotic Pathways

    1. Inhibitors of the Bcl-2 Protein Family as Sensitizers to Anticancer Agents

      • Daniel E. Johnson
      Pages 243-261

    2. Therapeutic Targeting of Apoptosis in Cancer

      • Timothy R. Wilson, Daniel B. Longley, Patrick G. Johnston
      Pages 263-278

    3. Peptides and Peptidomimetics as Cancer Therapy Sensitizing Agents

      • Shantanu Banerji, Sudharsana Rao Ande, Subbareddy Maddika, Versha Banerji, Iran Rashedi, Neil W. Owens et al.
      Pages 279-303

    4. Non-Peptidic Mimetics as Cancer-Sensitizing Agents

      • Ruud P. M. Dings, Mark Klein, Kevin H. Mayo
      Pages 305-325

    5. Sensitization of Cancer Cells to Cancer Therapies by Isoflavone and Its Synthetic Derivatives

      • Fazlul H. Sarkar, Yiwei Li
      Pages 327-335
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Keywords

About this book

Cancer chemotherapy can be traced back to the 1940’s and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies.

Reviews

From the reviews: “This book introduces emerging strategies, potential signaling pathways and biomolecules as key targets to sensitize resistant cancers. … detailed information and data can be obtained from the references listed at the end of each chapter. This book helps chemists to enrich their biological insight, and biologists to acquire new chemical strategies in reversing cancer resistance. … the book is also recommended to students in these fields. For scientists in industry and academia, and clinicians, this book provides an overview of current approaches … .” (Yoshihiko Kotake, ChemMedChem, Vol. 4, 2009)

Editors and Affiliations

  • University of California at Los Angeles, Los Angeles, USA

    Benjamin Bonavida

Bibliographic Information

  • Book Title: Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy

  • Editors: Benjamin Bonavida

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59745-474-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-934115-29-9Published: 25 July 2008

  • Softcover ISBN: 978-1-61737-928-4Published: 19 November 2010

  • eBook ISBN: 978-1-59745-474-2Published: 31 July 2008

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XXII, 420

  • Topics: Cancer Research, Oncology, Pharmacology/Toxicology, Immunology

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