Book 2008

Oxidative Stress in Aging

From Model Systems to Human Diseases

ISBN: 978-1-58829-991-8 (Print) 978-1-59745-420-9 (Online)

Table of contents (17 chapters)

  1. Front Matter

    Pages i-xiii

  2. Introduction

    1. Chapter

      Pages 3-10


    2. Chapter

      Pages 11-35

      The Basics of Oxidative Biochemistry

  3. The Role of Oxidative Stress in Aging

    1. Different Model Systems

      1. Chapter

        Pages 39-52

        Retrograde Response, Oxidative Stress, and Cellular Senescence

      2. Chapter

        Pages 53-65

        Reactive Oxygen Species in Molecular Pathways Controlling Aging in the Filamentous Fungus Podospora anserina

      3. Chapter

        Pages 67-79

        Oxidative Stress and Aging in the Budding Yeast Saccharomyces cerevisiae

      4. Chapter

        Pages 81-110

        Oxidative Stress and Aging in the Nematode Caenorhabditis elegans

      5. Chapter

        Pages 111-128

        Roles of Oxidative Stress in the Aging Process of Drosophila melanogaster

      6. Chapter

        Pages 129-146

        Does Oxidative Stress Limit Mouse Life Span?

      The Comparative Approach

      1. Chapter

        Pages 149-162

        Mitochondrial Free Radical Production and Caloric Restriction: Implications in Vertebrate Longevity and Aging

  4. Oxidative Stress in Human Aging and Diseases

    1. Chapter

      Pages 165-189

      Deregulation of Mitochondrial Function: A Potential Common Theme for Cardiovascular Disease Development

    2. Chapter

      Pages 191-211

      Oxidative Stress in Type 2 Diabetes Mellitus

    3. Chapter

      Pages 213-228

      DNA Oxidative Damage and Cancer

    4. Chapter

      Pages 229-251

      Oxidative Stress in Hypertension

    5. Chapter

      Pages 253-267

      Aging and Cardiac Ischemia—Mitochondria and Free Radical Considerations

    6. Chapter

      Pages 269-289

      Role of the Antioxidant Network in the Prevention of Age-Related Diseases

  5. Future

    1. Chapter

      Pages 293-307

      Reactive Oxygen Species as Signaling Molecules

    2. Chapter

      Pages 309-312

      Summary and Outlook

  6. Back Matter

    Pages 313-320