Ocular Transporters In Ophthalmic Diseases And Drug Delivery

Ophthalmology Research

Editors:

ISBN: 978-1-58829-958-1 (Print) 978-1-59745-375-2 (Online)

Table of contents (24 chapters)

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  1. Front Matter

    Pages i-xviii

  2. Transport in the Anterior Segment

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      Pages 3-16

      Aquaporins and Water Transport in the Cornea

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      Pages 17-46

      Roles of Corneal Epithelial Ion Transport Mechanisms in Mediating Responses to Cytokines and Osmotic Stress

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      Pages 47-57

      Vitamin C Transport, Delivery, and Function in the Anterior Segment of the Eye

  3. Transporters of the Ciliary Epithelium

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      Pages 61-86

      Mechanisms of Aqueous Humor Formation

  4. Lens Transporters

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      Pages 89-110

      Membrane Transporters

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      Pages 111-123

      Lens Na+, K+-ATPase

  5. Transport Across the Blood–Retinal Barrier

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      Pages 127-137

      Pathophysiology of Pericyte-containing Retinal Microvessels

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      Pages 139-154

      Molecular Mechanisms of the Inner Blood-Retinal Barrier Transporters

  6. Transport Across the Retinal Pigment Epithelium

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      Pages 157-184

      Regulation of Transport in the RPE

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      Pages 185-199

      Glucose Transporters in Retinal Pigment Epithelium Development

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      Pages 201-216

      Ca2+ Channels in the Retinal Pigment Epithelium

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      Pages 217-233

      Taurine Transport Pathways in the Outer Retina in Relation to Aging and Disease

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      Pages 235-253

      P-Glycoprotein Expression and Function in the Retinal Pigment Epithelium

  7. Transporters in the Retina

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      Book Chapter

      Pages 257-273

      The Retinal Rod NCKX1 and Cone/Ganglion Cell NCKX2 Na+/Ca2+-K+ Exchangers

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      Pages 275-292

      Excitatory Amino Acid Transporters in the Retina

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      Pages 293-313

      Localization and Function of Gamma Aminobutyric Acid Transporter 1 in the Retina

  8. Genetic Variants of Ocular Transporters

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      Book Chapter

      Pages 317-332

      Biochemical Defects Associated with Genetic Mutations in the Retina-Specific ABC Transporter, ABCR, and Macular Degenerative Diseases

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      Book Chapter

      Pages 333-353

      Glutamate Transporters and Retinal Disease and Regulation

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      Book Chapter

      Pages 355-371

      Glutamate Transport in Retinal Glial Cells during Diabetes

  9. Ocular Drug Delivery

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      Pages 375-397

      The Emerging Significance of Drug Transporters and Metabolizing Enzymes to Ophthalmic Drug Design

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