Transforming Growth Factor-β in Cancer Therapy, Volume I

Basic and Clinical Biology

Authors:

ISBN: 978-1-58829-714-3 (Print) 978-1-59745-292-2 (Online)

Table of contents (45 chapters)

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  1. Front Matter

    Pages i-xxiv

  2. Basic Concepts of TGF-β Signaling in Normal Physiology and Cancer Pathobiology

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-21

      Component Hardware for Transforming Growth Factor-β Signal Transduction: TGF-β Ligands, TGF-β Receptors, and Smads

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      Book Chapter

      Pages 23-35

      TGF-β Signaling in Homeostasis and Cancer

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      Book Chapter

      Pages 37-55

      TGF-β Availability: Latent TGF-β and Latent TGF-β Binding Proteins

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      Pages 57-75

      Biological Functions of Latent TGF-β-Binding Proteins and Activation of TGF-β

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      Book Chapter

      Pages 77-90

      Regulators of Smad2/3 Transcription and Phosphorylation

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      Book Chapter

      Pages 91-103

      Interaction of Smad4 and Embryonic Liver Fodrin-β-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression

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      Book Chapter

      Pages 105-123

      Regulation of Smad Activity by Phosphorylation

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      Book Chapter

      Pages 125-136

      Nuclear Targeting of TGF-β-Activated Smads in Normal and Tumor Biology

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      Book Chapter

      Pages 139-153

      Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival

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      Pages 155-167

      Transforming Growth Factor-β in Cancer Therapy: Smurfs in TGF-β Signaling and Regulation of Bone Homeostasis and Cancer

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      Book Chapter

      Pages 169-184

      Involvement of km23 Dynein Light Chains in TGF β Signaling

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      Book Chapter

      Pages 185-198

      TGF-β Signaling in Fibroblastic Cells and Oncogenesis

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      Book Chapter

      Pages 199-211

      Mechanisms of TGF-β-Induced Apoptosis in Cancer Cells

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      Book Chapter

      Pages 213-242

      Mechanisms of Cell Cycle Regulation by TGF-β Disabled in Cancer

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      Book Chapter

      Pages 243-257

      Transforming Growth Factor-β in Cancer Therapy

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      Book Chapter

      Pages 259-273

      TGF-β and Smad Signaling in Transcriptome Reprogramming During EMT

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      Book Chapter

      Pages 275-292

      Functional Interactions Between MMPs and TGF-β in Normal and Tumor Tissue

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      Book Chapter

      Pages 293-303

      Cooperation Between TGF-β and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function

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      Book Chapter

      Pages 305-315

      Interaction of Oncogenic Ras and TGFβ1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model

  3. TGF-β Superfamily Members in Normal and Tumor Biology

    1. Front Matter

      Pages 317-317

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      Book Chapter

      Pages 319-331

      Proteomics Analysis of TGFβ Superfamily Members

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