Apoptosis, Senescence, and Cancer

Editors:

ISBN: 978-1-58829-527-9 (Print) 978-1-59745-221-2 (Online)

Table of contents (28 chapters)

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  1. Front Matter

    Pages I-XVII

  2. Apoptosis and Alternative Modes of Cell Death

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-30

      The Intrinsic Pathway of Apoptosis

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      Book Chapter

      Pages 31-54

      The Extrinsic Pathway of Apoptosis

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      Book Chapter

      Pages 55-72

      Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survival

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      Book Chapter

      Pages 73-91

      Mitotic Catastrophe

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      Book Chapter

      Pages 93-107

      Autophagy and Autophagic Cell Death

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      Book Chapter

      Pages 109-122

      Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis

  3. Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis

    1. Front Matter

      Pages 123-123

    2. No Access

      Book Chapter

      Pages 125-144

      Structure and Function of the Telomere

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      Book Chapter

      Pages 145-157

      Overview of Senescence

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      Book Chapter

      Pages 159-171

      Contributions of Telomerase to Tumorigenesis

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      Book Chapter

      Pages 173-189

      The Role of Telomeres in Genomic Instability

  4. DNA Damage Response, Signaling Pathways, and Tumorigenesis

    1. Front Matter

      Pages 191-191

    2. No Access

      Book Chapter

      Pages 193-221

      Overview of the DNA Damage Checkpoint

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      Book Chapter

      Pages 223-241

      Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in Cancer

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      Book Chapter

      Pages 243-263

      Interplay Between γH2AX and 53BP1 Pathways in DNA Double-Strand Break Repair Response

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      Book Chapter

      Pages 265-278

      DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy

  5. Resistance and Sensitization

    1. Front Matter

      Pages 279-279

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      Book Chapter

      Pages 281-298

      Resistance/Signaling Pathways

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      Book Chapter

      Pages 299-312

      Ceramide and Multidrug Resistance

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      Book Chapter

      Pages 313-334

      Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling

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      Book Chapter

      Pages 335-357

      The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy

  6. Established Cancer Therapies

    1. Front Matter

      Pages 359-359

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      Book Chapter

      Pages 361-382

      Antimetabolites

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      Book Chapter

      Pages 383-406

      Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes

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