Opiate Receptors and Antagonists

From Bench to Clinic

Editors:

ISBN: 978-1-58829-881-2 (Print) 978-1-59745-197-0 (Online)

Table of contents (39 chapters)

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  1. Front Matter

    Pages i-xxiii

  2. Opioid Receptors

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      Book Chapter

      Pages 3-17

      Ultra-Low-Dose Opioid Antagonists Enhance Opioid Analgesia and Reduce Tolerance

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      Book Chapter

      Pages 19-44

      Upregulation of Opioid Receptors

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      Book Chapter

      Pages 45-65

      Imaging Human Brain Opioid Receptors: Applications to Substance Use Disorders

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      Pages 67-80

      Opioid Receptor Antagonist-Mediated Signaling in the Immune System

  3. Opioid Antagonists: Chemistry and Pharmacology

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      Book Chapter

      Pages 83-97

      The Chemistry and Pharmacology of μ-Opioid Antagonists

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      Book Chapter

      Pages 99-118

      Medicinal Chemistry of Kappa Opioid Receptor Antagonists

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      Book Chapter

      Pages 119-136

      The Chemistry and Pharmacology of Delta Opioid Antagonists

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      Book Chapter

      Pages 137-151

      Novel Opioid Antagonists with Mixed/Dual Selectivity

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      Book Chapter

      Pages 153-174

      Experimental Utility and Clinical Potential of Irreversible Opioid Antagonists

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      Book Chapter

      Pages 175-198

      Methylnaltrexone: A Peripherally Acting Opioid Antagonist

  4. Substance Abuse

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      Pages 201-226

      Opioid Antagonist Effects in Animal Models Related to Opioid Abuse: Drug Discrimination and Drug Self-Administration

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      Pages 227-245

      Naltrexone for Initiation and Maintenance of Opiate Abstinence

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      Book Chapter

      Pages 247-261

      Ultra-Low-Dose Naltrexone Decreases Dependence and Addictive Properties of Opioids

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      Book Chapter

      Pages 263-272

      Can a Combination Formulation Containing a Neutral Opiate Antagonist Decrease the Abuse of μ-Agonist Opiates

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      Book Chapter

      Pages 273-298

      Effects of Opioid Antagonists on the Abuse-Related Effects of Psychomotor Stimulants and Nicotine

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      Book Chapter

      Pages 299-314

      Potential Use of Opioid Antagonists in the Treatment of Marijuana Abuse and Dependence

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      Book Chapter

      Pages 315-332

      Naltrexone in Smoking Cessation: A Review of the Literature and Future Directions

  5. Alcohol and Ingestive Behaviors

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      Book Chapter

      Pages 335-369

      Opioid Antagonists and Ethanol's Ability to Reinforce Intake of Alcoholic Beverages: Preclinical Studies

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      Book Chapter

      Pages 371-386

      Clinical Use of Opioid Antagonists in the Treatment of Alcohol Dependence

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      Book Chapter

      Pages 387-406

      Preclinical Effects of Opioid Antagonists on Feeding and Appetite

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