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Cancer Drug Resistance

  • Book
  • © 2006

Overview

Editors:
  1. Beverly A. Teicher

    1. Genzyme Corporation, Framingham

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Physiological Resistance

    1. Front Matter

      Pages 1-1
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    2. The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors

      • Mark W. Dewhirst, Yiting Cao, Benjamin Moeller, Chuan-Yuan Li
      Pages 3-19

    3. Influence of Tumor pH on Therapeutic Response

      • Chang W. Song, Robert Griffin, Heon Joo Park
      Pages 21-42

    4. Tumor Oxygenation and Treatment Response

      • Sarah Jane Lunt, Richard P. Hill
      Pages 43-66

    5. Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance

      • Janusz W. Rak, Brenda Coomber, Joanne L. Yu
      Pages 67-103

    6. PET Imaging of Response and Resistance to Cancer Therapy

      • David A. Mankoff, Kenneth A. Krohn
      Pages 105-122

  3. Biological Resistance

    1. Front Matter

      Pages 123-123
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    2. Cancer Stem Cells Implications for Development of More Effective Therapies

      • Ilia Mantle, Gabriela Dontu, Suling Liu, Max S. Wicha
      Pages 125-136

    3. Therapeutic Resistance in Leukemia

      • William R. Waud
      Pages 137-150

    4. Tumor Site Implantation and Animal Model Selection in Oncology

      • Anibal A. Arjona, Enrique Alvarez
      Pages 151-159

    5. In Vivo Resistance

      • Beverly A. Teicher
      Pages 161-179

    6. Characteristics of the Metastatic Phenotype

      • Vladislava O. Melnikova, Menashe Bar-Eli
      Pages 181-200

    7. The Microenvironment and Drug Resistance

      • Patrice J. Morin
      Pages 201-210

  4. Biochemical Resistance

    1. Front Matter

      Pages 211-211
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    2. Glutathione and Glutathione S-Transferases in Drug Resistance

      • Victoria J. Findlay, Danyelle M. Townsend, Kenneth D. Tew
      Pages 213-221

    3. Metallothioneins in Drug Resistance

      • Faiyaz Notta, D. James Koropatnick
      Pages 223-239

    4. Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumors

      • Elena Monti
      Pages 241-260

    5. New and Revised Concepts in Multidrug Resistance

      • Susan E. Bates, John Deeken, Chaohong Fan, Robert W. Robey
      Pages 261-282

    6. Cisplatin Resistance

      • Zahid H. Siddik
      Pages 283-307
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Keywords

About this book

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Reviews

"...a resource to scientists of diverse specialties with interests relating to the repsonse of malignant disease to current and experimental therapies." - Neoplasma

"...an excellent book that is appropriate for scientists and clinicians with an interest in the basis of anticancer drug resistance." -Doody's Book Review, Weighted Numberical Score: 90 - 4 Stars!

Editors and Affiliations

  • Genzyme Corporation, Framingham

    Beverly A. Teicher

Bibliographic Information

  • Book Title: Cancer Drug Resistance

  • Editors: Beverly A. Teicher

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59745-035-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2006

  • Hardcover ISBN: 978-1-58829-530-9Published: 09 March 2006

  • Softcover ISBN: 978-1-61737-622-1Published: 09 December 2010

  • eBook ISBN: 978-1-59745-035-5Published: 09 November 2007

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XVI, 617

  • Topics: Oncology

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