Biological Reactive Intermediates III

Mechanisms of Action in Animal Models and Human Disease

ISBN: 978-1-4684-5136-8 (Print) 978-1-4684-5134-4 (Online)

Table of contents (100 chapters)

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  1. Front Matter

    Pages i-xv

  2. Years with Elizabeth and James Miller: in Appreciation

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      Pages 1-9

      Years with Elizabeth and James Miller: in Appreciation

  3. Chemistry and Biology of Biological Reactive Intermediates

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      Pages 11-30

      Reactivity and Tumorigenicity of Bay-Region Diol Epoxides Derived from Polycyclic Aromatic Hydrocarbons

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      Pages 31-40

      Chemistry of Covalent Binding: Studies with Bromobenzene and Thiobenzamide

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      Pages 41-51

      Role of Thiols in Protection Against Biological Reactive Intermediates

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      Book Chapter

      Pages 53-61

      Role of Parenchymal Versus Non-Parenchymal Cells on the Control of Biologically Reactive Intermediates

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      Book Chapter

      Pages 63-82

      Significance of Covalent Binding of Chemically Reactive Metabolites of Foreign Compounds to Proteins and Lipids

  4. Biology of Cytochrome P-450 and Related Aspects of the Mixed Function Oxidase

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      Book Chapter

      Pages 83-94

      Structure and Function of Cytochrome P-450

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      Pages 95-106

      Antibodies as Probes of Cytochrome P450 Isozymes

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      Pages 107-117

      Age and Sex Differences in Constitutive Forms of Cytochrome P-450 of Rat Liver Microsomes

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      Pages 119-144

      Identification of Intratissue Sites for Xenobiotic Activation and Detoxication

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      Pages 145-154

      Monoclonal Antibody-Directed Analysis of Cytochrome P-450

  5. Suicide Substrates of Cytochrome P-450

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      Book Chapter

      Pages 155-162

      Drug Interactions with Macrolide Antibiotics: Specificity of Pseudo-Suicide Inhibition and Induction of Cytochrome P-450

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      Book Chapter

      Pages 163-170

      Isomeric Composition of N-Alkylated Protoporphyrins Produced by Substituted Dihydropyridines in Vivo and in Vitro

  6. Characterization and Toxicological Significance of Phase II Enzymes

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      Book Chapter

      Pages 171-184

      UDP-Glucuronyltransferases and Their Toxicological Significance

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      Pages 185-193

      Expression and Sequence Analysis of Rat Liver Glutathione S-Transferase Genes

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      Book Chapter

      Pages 195-201

      Rat Cytosolic Epoxide Hydrolase

  7. Short Communications

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      Book Chapter

      Pages 203-212

      Multiplicity of Cytochrome P-450 in Morris Hepatoma

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      Book Chapter

      Pages 213-222

      The Metabolism of Benzene and Phenol by a Reconstituted Purified Phenobarbital-Induced Rat Liver Mixed Function Oxidase System

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      Book Chapter

      Pages 223-235

      Comparison of the Metabolism of Benzene and Its Metabolite Phenol in Rat Liver Microsomes

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      Book Chapter

      Pages 237-242

      Further Evidence for a Role of Isozymes of P450 in the Metabolism and Toxicity of Carbon Disulfide (CS2)

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