Book Volume 14 2014

Alcohol Use Disorders and the Lung

A Clinical and Pathophysiological Approach


ISBN: 978-1-4614-8832-3 (Print) 978-1-4614-8833-0 (Online)

Table of contents (16 chapters)

  1. Front Matter

    Pages i-x

  2. The Epidemiology of Alcohol Use and Lung Health

    1. Front Matter

      Pages 1-1

    2. Chapter

      Pages 3-6

      A Brief History of Alcohol Use and Abuse in Human History

    3. Chapter

      Pages 7-10

      Overview of the Evolving Recognition of the Health Effects of Excessive Alcohol Use Over the Past Two Centuries Including the Classic Citations

    4. Chapter

      Pages 11-17

      Current Definitions of Alcohol Use Disorders and the Use of Validated Questionnaires in Clinical Practice and Research

    5. Chapter

      Pages 19-34

      The Epidemiology of Alcohol Abuse and Pneumonia

    6. Chapter

      Pages 35-46

      The Epidemiology of Alcohol and Acute Respiratory Distress Syndrome

  3. The Pathophysiology of the “Alcoholic Lung”

    1. Front Matter

      Pages 47-47

    2. Chapter

      Pages 49-62

      Alcohol, the Upper Airway, and Mucociliary Dysfunction in the Conducting Airways

    3. Chapter

      Pages 63-81

      Alcohol and the Alveolar Macrophage

    4. Chapter

      Pages 83-101

      Alcohol and the Alveolar Epithelium

    5. Chapter

      Pages 103-114

      Alcohol-Mediated Oxidative Stress in the Airway: The Unique Role of Thiol Depletion

    6. Chapter

      Pages 115-132

      Alcohol and the Adaptive Immune Response in the Airway: Dendritic Cell and Lymphocyte Impairments

    7. Chapter

      Pages 133-153

      Alcohol Impairment of Granulocyte Function During Lung Infection

    8. Chapter

      Pages 155-171

      Disruption in the Dynamic Balance Between Transforming Growth Factor-β and Granulocyte/Macrophage Colony-Stimulating Factor Signaling Within the Alveolar Space of the Alcoholic Lung: Impact on Epithelial and Macrophage Function

    9. Chapter

      Pages 173-184

      Alcohol-Mediated Zinc Deficiency Within the Alveolar Space: A Potential Fundamental Mechanism Underlying Oxidative Stress and Cellular Dysfunction in the Alcoholic Lung

  4. Special Circumstances

    1. Front Matter

      Pages 185-185

    2. Chapter

      Pages 187-210

      The Impact of Alcohol Abuse on Multiple Organ Dysfunction in the Surgical Patient

    3. Chapter

      Pages 211-229

      Alcohol and HIV: Experimental and Clinical Evidence of Combined Impact on the Lung

    4. Chapter

      Pages 231-245

      Maternal Alcohol Use and the Neonate

  5. Back Matter

    Pages 247-252