Book 2013

Androgen-Responsive Genes in Prostate Cancer

Regulation, Function and Clinical Applications


ISBN: 978-1-4614-6181-4 (Print) 978-1-4614-6182-1 (Online)

Table of contents (20 chapters)

  1. Front Matter

    Pages i-ix

  2. Chapter

    Pages 1-11

    Roles of Androgen Receptor Coregulators and Cell Signaling in the Regulation of Androgen-Responsive Genes

  3. Chapter

    Pages 13-27

    Selective and Classical Androgen Response Elements in Androgen-Regulated Gene Expression

  4. Chapter

    Pages 29-41

    Negative Androgen-Response Elements in Androgen Target Genes

  5. Chapter

    Pages 43-58

    Chromatin Looping and Long Distance Regulation by Androgen Receptor

  6. Chapter

    Pages 59-84

    The Functionality of Prostate Cancer Predisposition Risk Regions Is Revealed by AR Enhancers

  7. Chapter

    Pages 85-100

    Mechanisms of ARE-Independent Gene Activation by the Androgen Receptor in Prostate Cancer Cells: Potential Targets for Better Intervention Strategies

  8. Chapter

    Pages 101-116

    Androgen Action, Wnt Signaling, and Prostate Tumorigenesis

  9. Chapter

    Pages 117-134

    Toward Revealing the Complexity of Androgen-Responsive Protein and Noncoding Transcripts in Prostate Cancer

  10. Chapter

    Pages 135-153

    Androgen-Responsive Gene Expression in Prostate Cancer Progression

  11. Chapter

    Pages 155-176

    Androgen Receptor-Regulated Genes in Prostate Cancer Initiation Versus Metastasis

  12. Chapter

    Pages 177-185

    Androgen-Independent Induction of Androgen-Responsive Genes by Interleukin-6 Regulation

  13. Chapter

    Pages 187-200

    The Effect of AR Overexpression on Androgen Signaling in Prostate Cancer

  14. Chapter

    Pages 201-213

    The Expression Signature of Androgen Receptor Splice Variants and Their Distinctive Transcriptional Activities in Castration-Resistant Prostate Cancer

  15. Chapter

    Pages 215-225

    Androgen Regulation of the Cell Cycle in Prostate Cancer

  16. Chapter

    Pages 227-255

    Androgen Receptor Signaling Interactions Control Epithelial–Mesenchymal Transition (EMT) in Prostate Cancer Progression

  17. Chapter

    Pages 257-271

    Androgen Receptor Regulation of Serum Response Factor Signaling in Prostate Cancer

  18. Chapter

    Pages 273-283

    Regulation of Angiogenesis by Androgen-Responsive Gene EAF2

  19. Chapter

    Pages 285-305

    The Role of miR-21, an Androgen-Regulated MicroRNA, in Prostate Cancer

  20. Chapter

    Pages 307-328

    Androgen-Dependent Oncogenic Activation of ETS Transcription Factors by Recurrent Gene Fusions in Prostate Cancer: Biological and Clinical Implications

  21. Chapter

    Pages 329-340

    Clusterin as a Target for Treatment of Castration-Resistant Prostate Cancer

  22. Back Matter

    Pages 341-348