Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications

Proceedings of the 6th International Conference on Sodium Calcium Exchange

Editors:

ISBN: 978-1-4614-4755-9 (Print) 978-1-4614-4756-6 (Online)

Table of contents (38 chapters)

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  1. Front Matter

    Pages i-xxv

  2. Historical Perspective

    1. Front Matter

      Pages 1-1

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      Pages 3-15

      Livin’ with NCX and Lovin’ It: A 45 Year Romance

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      Pages 17-23

      20 Years from NCX Purification and Cloning: Milestones

  3. Structural and Functional Aspects of NCX

    1. Front Matter

      Pages 25-25

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      Book Chapter

      Pages 27-33

      Ca2+ Regulation in the Na+/Ca2+ Exchanger Features a Dual Electrostatic Switch Mechanism

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      Pages 35-48

      Molecular Determinants of Allosteric Regulation in NCX Proteins

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      Pages 49-54

      NCX1: Mechanism of Transport

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      Pages 55-63

      Structural Studies of the Ca2+ Regulatory Domain of Drosophila Na+/Ca2+ Exchanger CALX

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      Pages 65-78

      Interplay of Ca2+ and Mg2+ in Sodium-Calcium Exchanger and in Other Ca2+-Binding Proteins: Magnesium, Watchdog That Blocks Each Turn if Able

  4. Structural and Functional Aspects of NCKX

    1. Front Matter

      Pages 79-79

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      Book Chapter

      Pages 81-94

      Functional and Structural Properties of the NCKX2 Na+-Ca2+/K+ Exchanger: A Comparison with the NCX1 Na+/Ca2+ Exchanger

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      Pages 95-107

      NCKX5, a Natural Regulator of Human Skin Colour Variation, Regulates the Expression of Key Pigment Genes MC1R and Alpha-MSH and Alters Cholesterol Homeostasis in Normal Human Melanocytes

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      Book Chapter

      Pages 109-121

      Expression and Regulation of Sodium/Calcium Exchangers, NCX and NCKX, in Reproductive Tissues: Do They Play a Critical Role in Calcium Transport for Reproduction and Development?

  5. Genetic and Epigenetic Regulation

    1. Front Matter

      Pages 123-123

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      Pages 125-135

      Transcriptional Pathways and Potential Therapeutic Targets in the Regulation of Ncx1 Expression in Cardiac Hypertrophy and Failure

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      Pages 137-145

      Transcriptional Regulation of ncx1 Gene in the Brain

  6. Regulatory Mechanisms of NCX

    1. Front Matter

      Pages 147-147

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      Book Chapter

      Pages 149-161

      Metabolic Regulation of the Squid Nerve Na+/Ca2+ Exchanger: Recent Developments

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      Book Chapter

      Pages 163-173

      Regulation of Sodium-Calcium Exchanger Activity by Creatine Kinase

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      Pages 175-190

      Coordinated Regulation of Cardiac Na+/Ca2+ Exchanger and Na+-K+-ATPase by Phospholemman (FXYD1)

  7. Subcellular Localization and Function of NCX in Ca-Storing Organelles and Mitochondria

    1. Front Matter

      Pages 191-191

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      Pages 193-201

      Mitochondria Na+-Ca2+ Exchange in Cardiomyocytes and Lymphocytes

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      Pages 203-209

      New Insights in Mitochondrial Calcium Handling by Sodium/Calcium Exchanger

  8. NCX in Neurodegenerative Diseases

    1. Front Matter

      Pages 211-211

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      Book Chapter

      Pages 213-222

      Genetically Modified Mice as a Strategy to Unravel the Role Played by the Na+/Ca2+ Exchanger in Brain Ischemia and in Spatial Learning and Memory Deficits

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      Pages 223-240

      NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning

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      Pages 241-249

      The Role of the Mitochondrial NCX in the Mechanism of Neurodegeneration in Parkinson’s Disease

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