Advances in DNA Repair in Cancer Therapy


ISBN: 978-1-4614-4740-5 (Print) 978-1-4614-4741-2 (Online)

Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii

  2. Chapter

    Pages 1-23

    Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs

  3. Chapter

    Pages 25-44

    DNA-PK, a Pharmacological Target in Cancer Chemotherapy and Radiotherapy?

  4. Chapter

    Pages 45-74

    Growth Factor Receptor Signaling, DNA Damage Response, and Cancer Cell Susceptibility to Chemotherapy and Relapses

  5. Chapter

    Pages 75-128

    The Relationship Between DNA-Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy

  6. Chapter

    Pages 129-142

    Important Roles of ERCC1 in DNA Repair and Targeted Therapy

  7. Chapter

    Pages 143-155

    The Role of BRCA1 and BRCA2 in Anticancer Drug Therapy

  8. Chapter

    Pages 157-166

    DNA-PK in CLL Chemotherapy

  9. Chapter

    Pages 167-186

    Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair

  10. Chapter

    Pages 187-209

    Cellular Protection Against the Antitumor Drug Bleomycin

  11. Chapter

    Pages 211-228

    ATR as a Therapeutic Target

  12. Chapter

    Pages 229-279

    Telomeres, Telomerase, and DNA Damage Response in Cancer Therapy

  13. Chapter

    Pages 281-302

    RAD51 Is a Key Protein of DNA Repair and Homologous Recombination in Humans

  14. Back Matter

    Pages 303-312