Complement Therapeutics

Editors:

ISBN: 978-1-4614-4117-5 (Print) 978-1-4614-4118-2 (Online)

Table of contents (21 chapters)

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  1. Front Matter

    Pages i-viii

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    Book Chapter

    Pages 1-22

    Progress and Trends in Complement Therapeutics

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    Pages 23-40

    Inhibition of the Serine Proteases of the Complement System

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    Pages 41-53

    The Role of MASP-1/3 in Complement Activation

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    Pages 55-81

    Membrane-Bound Complement Regulatory Proteins as Biomarkers and Potential Therapeutic Targets for SLE

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    Pages 83-96

    DAF as a Therapeutic Target for Steroid Hormones: Implications for Host–Pathogen Interactions

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    Pages 97-110

    Targeting gC1qR Domains for Therapy Against Infection and Inflammation

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    Pages 111-121

    The Alternative C5a Receptor Function

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    Pages 123-136

    The Effects of Selective Complement and CD14 Inhibition on the E. coli-Induced Tissue Factor mRNA Upregulation, Monocyte Tissue Factor Expression, and Tissue Factor Functional Activity in Human Whole Blood

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    Pages 137-154

    CR2-Mediated Targeting of Complement Inhibitors: Bench-to-Bedside Using a Novel Strategy for Site-Specific Complement Modulation

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    Pages 155-172

    Paroxysmal Nocturnal Hemoglobinuria and the Complement System: Recent Insights and Novel Anticomplement Strategies

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    Pages 173-187

    Defective Complement Action and Control Defines Disease Pathology for Retinal and Renal Disorders and Provides a Basis for New Therapeutic Approaches

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    Pages 189-196

    C3 Glomerulonephritis/CFHR5 Nephropathy Is an Endemic Disease in Cyprus: Clinical and Molecular Findings in 21 Families

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    Pages 197-206

    Complement-Targeted Therapeutics in Periodontitis

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    Pages 207-218

    Complement System Activation in Cardiac and Skeletal Muscle Pathology: Friend or Foe?

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    Pages 219-232

    Innate Immunity as Orchestrator of Bone Marrow Homing for Hematopoietic Stem/Progenitor Cells

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    Pages 233-246

    Complement-Mediated Microvascular Injury Leads to Chronic Rejection

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    Pages 247-255

    Targeting Complement at the Time of Transplantation

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    Pages 257-270

    Evaluation of the Blood Compatibility of Materials, Cells, and Tissues: Basic Concepts, Test Models, and Practical Guidelines

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    Pages 271-282

    Noninvasive Detection of Complement Activation Through Radiologic Imaging

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    Book Chapter

    Pages 283-300

    Highly Multiplexed Proteomic Platform for Biomarker Discovery, Diagnostics, and Therapeutics

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