Book 2012

LC-MS in Drug Bioanalysis


ISBN: 978-1-4614-3827-4 (Print) 978-1-4614-3828-1 (Online)

Table of contents (14 chapters)

  1. Front Matter

    Pages i-xi

  2. Chapter

    Pages 1-32

    Internal Standards for Quantitative LC-MS Bioanalysis

  3. Chapter

    Pages 33-66

    Method Development, Validation, and Sample Analysis for Regulated Quantitative Bioanalysis Using LC-MS/MS

  4. Chapter

    Pages 67-80

    Impact of Sampling Paper/Cards on Bioanalytical Quantitation via Dried Blood Spots by Liquid Chromatography-Mass Spectrometry

  5. Chapter

    Pages 81-107

    Highly Sensitive Pharmaceutical and Clinical Analysis Using Selective Solid-Phase Extraction Coupled to Microflow Liquid Chromatography and Isotope-Dilution Mass Spectrometry

  6. Chapter

    Pages 109-126

    Pitfalls of LC-MS/MS in the Clinical Laboratory

  7. Chapter

    Pages 127-141

    Therapeutic Drug Monitoring to Support Clinical Pharmacogenomics

  8. Chapter

    Pages 143-175

    Liquid Chromatography-Mass Spectrometry for the Determination of Antidepressants and Some of their Major Metabolites in Human Biological Matrices

  9. Chapter

    Pages 177-195

    The Analysis of Antipsychotic Drugs in Human Biosamples by LC-MS

  10. Chapter

    Pages 197-250

    Therapeutic Drug Monitoring of Targeted Anticancer Therapy. Tyrosine Kinase Inhibitors and Selective Estrogen Receptor Modulators: A Clinical Pharmacology Laboratory Perspective

  11. Chapter

    Pages 251-286

    Applications of Mass Spectrometry in Analyses of Steroid Hormones

  12. Chapter

    Pages 287-347

    Liquid Chromatography-Mass Spectrometric Analysis of Tropane Alkaloids in Mammalian Samples: Techniques and Applications

  13. Chapter

    Pages 349-398

    Analysis of Illicit Drugs in Human Biological Samples by LC-MS n

  14. Chapter

    Pages 399-422

    Use of Matrix Assisted Laser Desorption/Ionization Imaging Mass Spectrometry (MALDI-IMS) in the Development of Novel Small Molecule Drugs

  15. Chapter

    Pages 423-465

    A Planar Integrated Micro-mass Spectrometer

  16. Back Matter

    Pages 467-469