Book 2013

p53 in the Clinics


ISBN: 978-1-4614-3675-1 (Print) 978-1-4614-3676-8 (Online)

Table of contents (18 chapters)

  1. Front Matter

    Pages i-x

  2. Chapter

    Pages 1-23

    TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer

  3. Chapter

    Pages 25-46

    The Inheritance of p53

  4. Chapter

    Pages 47-64

    p53: Guardian of the Metabolome

  5. Chapter

    Pages 65-76

    The p53 Family and Stem Cell Biology

  6. Chapter

    Pages 77-93

    Mutant p53-Driven Tumorigenesis

  7. Chapter

    Pages 95-108

    Humanised Mouse Models: Targeting the Murine p53 Locus with Human Sequences

  8. Chapter

    Pages 109-126

    p53 Models for Mammary Carcinogenesis

  9. Chapter

    Pages 127-146

    TP53 Somatic Mutations: Prognostic and Predictive Value in Human Cancers

  10. Chapter

    Pages 147-165

    Assessing TP53 Status in Human Tumors: Lessons from Breast Cancer

  11. Chapter

    Pages 167-188

    TP53 Germline Mutations: Genetics of Li–Fraumeni Syndrome

  12. Chapter

    Pages 189-208

    Tp53 Gene Therapy for Cancer Treatment and Prevention

  13. Chapter

    Pages 209-229

    Upstream Targets in the p53 Pathway

  14. Chapter

    Pages 231-255

    p53-Reactivating Molecules as Research Tools and Anticancer Drugs

  15. Chapter

    Pages 257-273

    Targeting Mutant p53 for Improved Cancer Therapy

  16. Chapter

    Pages 275-287

    p53 Immunotherapy of Cancer

  17. Chapter

    Pages 289-303

    Designing p53 Trials: A Surgical Oncologists View

  18. Chapter

    Pages 305-326

    p53 in the Clinic: A Pathologist’s View

  19. Chapter

    Pages 327-343

    Genetic Counseling for TP53 Germline Mutations

  20. Back Matter

    Pages 345-355